CORE--CONTRACTILITY

可伸缩性核心的目的是提供协作 具有可靠和有效措施的项目调查人员 全横纹肌和横纹肌条的收缩特性 横隔肌纤维，数据统计分析，和 对结构-功能关系的解释。核心还将 为教职员工提供指导和培训机会 希望学习技术的受训者。肌肉纤维被激活时 尝试收缩或缩短。无论激活的肌纤维是否变短， 保持相同长度或拉伸取决于相互作用 所产生的力和载荷之间的关系。对于横纹肌， 收缩能力被定义为肌肉纤维发展的能力 固定长度或等长收缩时的力，缩短或缩短时的力 节律收缩，以及在伸长或节律收缩过程中。 我们的工作假设是横纹肌的收缩能力是 复杂的现象和提供可靠和有效的测量 需要精密的设备和训练有素的肌肉机械师 进行测量并对结果进行分析和解释。因此， 检验与减少的潜在机制有关的假说 疾病和老年动物纹状肌的严格收缩， 一个可伸缩性核心是必要的。在这三项中的每一项中的减损 各种类型的宫缩可能发生在任何年龄，由于受伤或疾病或 伴随着衰老而来的棘手问题。在收缩能力方面的损伤， 无论是由于受伤、疾病还是年老，限制每天的活动 生活和降低生活质量，特别是对病人和老年人 老年人。

The purpose of the Contractility Core is to provide collaborating investigators in the Program Project with reliable and valid measures of the contractile properties of whole striated muscles and of strips of diaphragm muscle fibers, statistical analysis of the data, and interpretation of the structure-function relationships. The Core will also provide opportunities for instruction and training for faculty and trainees who wish to learn the techniques. Muscle fibers when activated attempt to contract or shorten. Whether an activated myofiber shortens, stays at the same length or is stretched depends on the interaction between the force developed and the load. For striated muscle, contractility is defined as the capability of muscle fibers to develop force during fixed length or isometric contractions, during shortening or miometric contractions, and during lengthening or pliometric contractions. Our working hypothesis is that contractility of striated muscles is a complex phenomenon and the provision of reliable and valid measurements requires sophisticated equipment and highly trained muscle mechanicists to make the measurements and analyze and interpret the results. Consequently, to test hypothesis relating the underlying mechanisms of the reduced contractility of striated muscles in diseased and old animals rigorously, a Contractility Core is a necessity. Impairments during each of the three types of contraction may occur at any age due to injury or disease or as an intractable concomitant of aging. The impairments in contractility, whether due to injury, disease, or old age, limit the activities of daily living and reduce the quality of life, particularly for the sick and the elderly.