CORE--CONTRACTILITY

收缩核心的目的是提供协作 项目中的调查人员，采取可靠有效的措施， 整个横纹肌和横纹肌条的收缩特性 膈肌纤维，数据的统计分析，以及 结构-功能关系的解释。核心也将 为教师提供指导和培训的机会， 希望学习技术的学员。激活时的肌纤维 试图收缩或缩短。无论激活的肌纤维是否缩短， 保持相同的长度或被拉伸取决于相互作用 产生的力和负载之间。对于横纹肌， 收缩性被定义为肌肉纤维发育的能力 固定长度或等长收缩期间的力，缩短或 微收缩，以及在延长或微收缩期间。 我们的工作假设是横纹肌的收缩性是一个 复杂的现象和提供可靠有效的测量 需要精密的设备和训练有素的肌肉机械师， 进行测量并分析和解释结果。因此，委员会认为， 为了检验有关减少的潜在机制的假设， 在患病和老年动物中横纹肌的收缩性， 收缩核心是必需的三个阶段中的每一个阶段 由于受伤或疾病，收缩类型可能发生在任何年龄， 衰老的一个棘手的伴随物。收缩力受损， 无论是由于受伤、疾病或年老， 生活和降低生活质量，特别是对病人和 老人

The purpose of the Contractility Core is to provide collaborating investigators in the Program Project with reliable and valid measures of the contractile properties of whole striated muscles and of strips of diaphragm muscle fibers, statistical analysis of the data, and interpretation of the structure-function relationships. The Core will also provide opportunities for instruction and training for faculty and trainees who wish to learn the techniques. Muscle fibers when activated attempt to contract or shorten. Whether an activated myofiber shortens, stays at the same length or is stretched depends on the interaction between the force developed and the load. For striated muscle, contractility is defined as the capability of muscle fibers to develop force during fixed length or isometric contractions, during shortening or miometric contractions, and during lengthening or pliometric contractions. Our working hypothesis is that contractility of striated muscles is a complex phenomenon and the provision of reliable and valid measurements requires sophisticated equipment and highly trained muscle mechanicists to make the measurements and analyze and interpret the results. Consequently, to test hypothesis relating the underlying mechanisms of the reduced contractility of striated muscles in diseased and old animals rigorously, a Contractility Core is a necessity. Impairments during each of the three types of contraction may occur at any age due to injury or disease or as an intractable concomitant of aging. The impairments in contractility, whether due to injury, disease, or old age, limit the activities of daily living and reduce the quality of life, particularly for the sick and the elderly.