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CORE--NMR SPECTROSCOPY FACILITY

核磁共振波谱仪

基本信息

批准号：
6397814
负责人：
MICHAEL WEISS
金额：
$ 28.97万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-08-01 至 2002-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6397814
关键词：
biomedical facility fluorescence spectrometry nuclear magnetic resonance spectroscopy

项目摘要

The University of Chicago Cancer Research Center (UCCRC) Core Facility in Nuclear Magnetic Resonance (NMR) copy offers state-of-the-art instrumentation in multidimensional heteronuclear NMR spectroscopy and phase-modulation fluorescence spectroscopy for application to basic research in molecular oncology. These methods enable the structure and dynamics of cancer-related macromolecules (such as oncoproteins and growth factors) and drug interactions to be investigated in solution. The goals of the facility are: (a) to provide advice to faculty and trainees regarding the capabilities and appropriate scientific role of such methods in the context of their fields, (b) to provide "hands-on" teaching and training, (c) to provide 2D, 3D and 4D homonuclear and heteronuclear NMR spectra for analysis of the structures of proteins, carbohydrates and nucleic acids in solution, (d) to provide heteronuclear relaxation times at multiple field strengths for analysis of macromolecular dynamics, (e) to provide complementary steady-state and phase-modulation fluorescence spectra of macromolecules, and (f) to provide a workstation for computer-based data analysis. The NMR spectrometers were purchased in 1995 using funds from the Division of the Biological Sciences and peer-reviewed matching funds from the National Cancer Institute. The Facility is located in the newly constructed Biological Sciences Learning Center/Jules F. Knapp Medical Research Building. Scheduling information and data output from the instruments are accessible to faculty in their offices via high-speed computer data links.

芝加哥大学癌症研究中心 (UCCRC) 核心设施核磁共振 (NMR) 副本提供最先进的技术多维异核核磁共振光谱仪和相位调制荧光光谱法的应用分子肿瘤学研究。这些方法使结构和癌症相关大分子（例如癌蛋白和生长因子）和药物相互作用在溶液中进行研究。这该设施的目标是：(a) 向教师和学员提供建议关于此类的能力和适当的科学作用其领域背景下的方法，(b) 提供“实践” 教学和培训，(c) 提供 2D、3D 和 4D 同核和用于分析蛋白质结构的异核核磁共振谱，溶液中的碳水化合物和核酸，(d)提供异核多个场强下的弛豫时间用于分析大分子动力学，（e）提供互补的稳态和大分子的相位调制荧光光谱，以及（f）提供基于计算机的数据分析工作站。核磁共振光谱仪是 1995 年使用该部门的资金购买的。生物科学和国家同行评审的配套资金癌症研究所。该设施位于新建的生物科学学习中心/Jules F. Knapp 医学研究建筑。仪器的调度信息和数据输出是教师可以在办公室通过高速计算机数据访问链接。