USE OF BIOMARKERS IN DETECTING BRAIN INJURY FOLLOWING HIE

使用生物标志物检测 HIE 后的脑损伤

• 批准号: 7605477
• 负责人: MICHAEL WEISS
• 金额: $ 1.23万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605477
• 关键词: Asphyxia; Biological Markers; Blood; Brain; Brain Injuries; Cerebral Palsy; Collagen; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Data; Disabled Persons; Epilepsy; Etiology; Exhibits; Funding; Future; Grant; Infant; Institution; Laboratories; Learning Disabilities; Mental Retardation; Monitor; Neuronal Injury; Neuropsychology; Newborn Infant; Outcome; Pathology; Patients; Recovery; Research; Research Personnel; Resources; Respiratory distress; Sepsis; Septic Toxemia; Severities; Source; Survivors; Testing; Therapeutic Intervention; United States National Institutes of Health; Urine; Vascular Diseases; Very Low Birth Weight Infant; clinical application; design; handicapping condition; neonatal hypoxic-ischemic brain injury; neonate; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoxic ischemic encephalopathy (HIE) is the brain manifestation of systemic asphyxia. Systemic asphyxia occurs in about 3 out of 1,000 full-term infants and in nearly 60% of very low birth weight (premature) newborns. Between 20-50% of asphyxiated babies who exhibit HIE die during the newborn period. Of the survivors, up to 25% have permanent neuropsychologic handicaps in the form of cerebral palsy, with or without associated mental retardation, learning disabilities, or epilepsy. Systemic asphyxia, with the end consequences being HIE, has many different etiologies. Systemic asphyxia may occur prior to delivery (placental abruptio, toxemia, maternal collagen vascular disease), during delivery (prolonged labor, difficult delivery, abnormal presentation) or after delivery (sepsis, infectious disease, respiratory distress). Currently, there is no reliable laboratory test to assess the degree of neuronal injury. This study in neonates suffering HIE is designed to collect preliminary data characterizing the association between the concentrations of selected blood and urine biomarkers and the physical exam and neuroimaging findings of these neonates. Identification of biomarkers of brain injury in neonates will have several important future clinical applications: 1) to stratify patients by the severity of their HIE; 2) to better monitor the progression of brain injury-induced pathology and recovery; 3) to monitor the effects of therapy/intervention; and 4) to predict outcome more accurately after HIE.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 缺氧缺血性脑病（HIE）是全身性窒息的脑部表现。 大约千分之三的足月婴儿和近 60% 的极低出生体重（早产）新生儿会发生系统性窒息。 20-50% 表现出 HIE 的窒息婴儿会在新生儿期死亡。 在幸存者中，高达 25% 的人患有脑瘫等永久性神经心理障碍，伴有或不伴有智力低下、学习障碍或癫痫。 系统性窒息的最终后果是 HIE，有许多不同的病因。 全身性窒息可能发生在分娩前（胎盘早剥、毒血症、母体胶原血管疾病）、分娩过程中（产程延长、分娩困难、胎先露异常）或分娩后（败血症、传染病、呼吸窘迫）。 目前，没有可靠的实验室测试来评估神经元损伤的程度。 这项针对患有 HIE 的新生儿的研究旨在收集初步数据，描述选定的血液和尿液生物标志物浓度与这些新生儿的体检和神经影像学结果之间的关联。新生儿脑损伤生物标志物的鉴定将在未来有几个重要的临床应用：1）根据 HIE 的严重程度对患者进行分层； 2）更好地监测脑损伤引起的病理进展和恢复情况； 3）监测治疗/干预的效果； 4) 更准确地预测 HIE 后的结果。