CORE--TRANSGENIC ANIMAL

转基因动物/胚胎干细胞共享设施成立于1991年，并于1995年成为癌症中心共享设施。其目的是为癌症中心的研究人员提供高标准的质量控制和效率的无病原体转基因小鼠。该服务还向首次使用的用户提供咨询、库存的重新获取、冷冻保存和相关技术。自成立以来，它已经注入了500个基因和40个ES细胞克隆，包括“敲除”和“敲入”模型。已经提供了超过35000只创始动物。在过去的两年里，该机构每年为来自五个项目领域的23名不同资金的癌症中心成员提供248天的工作时间。由于数量和收入来源的增加，向调查员收取的费用从1,500美元/项目降至1999年的750美元/项目。根据遗传学设施和教职员工的机构扩展，预计将进一步扩大利用。

The Transgenic Animal/Embryonic Stem Cell Shared Facility was initiated in 1991 and became a Cancer Center shared facility in 1995. Its purpose is to provide Cancer Center investigators with pathogen-free transgenic mice with high standards of quality control and efficiency. The service also provides advice and consultation to first-time users, re- derivation of stocks, cryopreservation and associated technologies. Since inception, it has injected 500 genes and 40 ES cell clones including "knock-out" and "knock-in" models. Over 3,5000 founder animals have been provided. Over the past two years, the facility has provided 248 effort days per year with 23 different funded Cancer Center members from five program areas. Increasing volume and sources of revenue has allowed a reduction in charges to investigators from $1,500/project to $750/project in 199. Further expansion of utilization is projected based on institutional expansion of genetics facilities and faculty members.