CORE--TRANSGENIC ANIMAL

描述：(申请人描述)转基因动物/胚胎干细胞 细胞共享设施成立于1991年，成为共享的癌症中心 工厂于1995年建成。其目的是为癌症中心的研究人员提供 无病原体转基因小鼠，质量控制和高标准 效率。这项服务还首次提供咨询和咨询 用户、库存的重新派生、冷冻保存和相关技术。 自成立以来，它已经注入了500个基因和40个ES细胞克隆，包括 “淘汰赛”和“敲进赛”的模特。已经有超过3500只创始动物 如果是这样的话。在过去的两年里，该设施已经提供了248个工作日 每年与来自五个项目的23名不同资金的癌症中心成员 区域。不断增加的数量和收入来源允许减少 1999年，向调查人员收取的费用从每个项目1500美元增加到750美元。进一步 利用的扩展是基于机构扩展的预测 遗传学设施和教职员工。

Description: (Applicant's Description) The Transgenic Animal/Embryonic Stem Cell Shared Facility was initiated in 1991 and became a Cancer Center shared facility in 1995. Its purpose is to provide Cancer Center investigators with Pathogen-Free transgenic mice with high standards of quality control and efficiency. The service also provides advice and consultation to first time users, rederivation of stocks, cryopreservation and associated technologies. Since inception, it has injected 500 genes and 40 ES cell clones including "knockout" and "knock in" models. Over 3,500 founder animals have been provided. Over the past two years, the facility has provided 248 effort days per year with 23 different funded Cancer Center members from five program areas. Increasing volume and sources of revenue has allowed a reduction in charges to investigators from $1,500/project to $750/project in 1999. Further expansion of utilization is projected based on institutional expansion of genetics facilities and faculty members.