AUTOGRAFTING FOR LYMPHOMA
自体移植治疗淋巴瘤
基本信息
- 批准号:6395686
- 负责人:
- 金额:$ 22.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-03-13 至 2001-01-31
- 项目状态:已结题
- 来源:
- 关键词:Hodgkin's disease autologous transplantation bone marrow transplantation clinical research cyclophosphamide cytokine dosage hematopoietic tissue transplantation human subject human therapy evaluation lomustine lymphokine activated killer cell neoplasm /cancer chemotherapy neoplasm /cancer immunotherapy neoplasm /cancer relapse /recurrence nonHodgkin's lymphoma
项目摘要
It is the objective of our studies to improve the results of treatment
with high dose therapy and autografting in Hodgkin's disease and the
non-Hodgkin's lymphomas. We intend to accomplish this goal through
the study of novel preparatory regimens and post-transplant
immunotherapy. Complementary pathology studies are planned to better
define biologic correlates of the clinical results.
The proposed clinical studies build on our previous research in these
diseases. A new preparatory regimen (CCNU, VP16, cyclophosphamide)
developed at Stanford University will be evaluated in patients with
low risk Hodgkin's disease. Multiple cycle high dose therapy has been
developed to reduce relapse in high risk Hodgkin's disease patients.
We will compare the efficacy and toxicity of high dose sequential
chemotherapy with our standard preparatory regimen in a Phase III
trial in non-Hodgkin's lymphoma. Correlations will be made with a
number of biologic parameters assessed in lymphoma tissues in order
to further elucidate factors that may predict the treatment outcome
after high dose therapy and autografting. All autografted patients
will be studied by sensitive molecular and cytogenetic techniques
designed to predict genomic instability and the risk for treatment-
related myelodysplasia or acute leukemia. In collaboration with
investigators in Project III, we will study the feasibility and
toxicity of infusing cytokine-induced killer cells into patients with
refractory non-Hodgkin's lymphoma. These CIK cells represent a novel
therapeutic which, when used as an adjunct to high dose therapy and
autografting, may reduce the major problem of relapse after
autografting.
The studies in Project II are based on past accomplishments in the
research laboratory and the clinic. Analysis of previous experience
allows us to define risk groups in Hodgkin's disease and structure
preparatory regimens accordingly. We plan a comprehensive approach
to the study of non-Hodgkin's lymphoma by characterizing lymphoma
tissues, purging lymphoma from the apheresis product, comparing two
preparatory regimens, and introducing a novel post-transplant
immunotherapy to the clinic. The potential for myelodysplasia or
acute leukemia as a late effect of high dose therapy will be studied
prospectively in all patients. Project II will serve as a clinical
resource for other subprojects.
我们研究的目的是改善治疗效果
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SANDRA J. HORNING其他文献
SANDRA J. HORNING的其他文献
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{{ truncateString('SANDRA J. HORNING', 18)}}的其他基金
EFFICACY OF ANTI-CD20 ANTIBODY IN LYMPHOCYTE PREDOMINANT HODGKIN'S DISEASE
抗 CD20 抗体在淋巴细胞为主型霍奇金病中的疗效
- 批准号:
7605162 - 财政年份:2007
- 资助金额:
$ 22.14万 - 项目类别:
CLINICAL TRIAL: EVALUATE THE EFFICACY OF ANTI-CD20 ANTIBODY IN LYMPHOCYTE PREDOM
临床试验:评估抗 CD20 抗体在前淋巴细胞中的功效
- 批准号:
7717845 - 财政年份:2007
- 资助金额:
$ 22.14万 - 项目类别:
EFFICACY OF ANTI-CD20 ANTIBODY IN LYMPHOCYTE PREDOMINANT HODGKIN'S DISEASE
抗 CD20 抗体在淋巴细胞为主型霍奇金病中的疗效
- 批准号:
7375191 - 财政年份:2005
- 资助金额:
$ 22.14万 - 项目类别:
EFFICACY OF ANTI-CD20 ANTIBODY IN LYMPHOCYTE PREDOMINANT HODGKIN'S DISEASE
抗 CD20 抗体在淋巴细胞为主型霍奇金病中的疗效
- 批准号:
7202019 - 财政年份:2004
- 资助金额:
$ 22.14万 - 项目类别:
TREATMENT OF PATIENTS WITH LARGE B-CELL LYMPHOMA
大 B 细胞淋巴瘤患者的治疗
- 批准号:
7202057 - 财政年份:2004
- 资助金额:
$ 22.14万 - 项目类别:
A Phase II Study: Rituximab, rhuMAb VEGF (bevacizumab)
II 期研究:利妥昔单抗、rhuMAb VEGF(贝伐珠单抗)
- 批准号:
6980946 - 财政年份:2003
- 资助金额:
$ 22.14万 - 项目类别:
Evaluate the Efficacy of Anti-CD20 Antibody in Hodgkin's
评估抗 CD20 抗体在霍奇金氏病中的疗效
- 批准号:
6980890 - 财政年份:2003
- 资助金额:
$ 22.14万 - 项目类别:
PHASE II STUDY OF IODINE 131 ANTI BI ANTIBODY FOR NON HODGKINS LYMPHOMA
碘131抗双抗体治疗非霍奇金淋巴瘤的II期研究
- 批准号:
6486028 - 财政年份:2000
- 资助金额:
$ 22.14万 - 项目类别:
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