Core--Animal Handling

这一核心的主要目标有三个方面。1)根据本计划项目资助中所有研究人员的需要生产发育阶段的动物(如怀孕、哺乳期或退化期)，2)提供针对乳腺的一般外科支持，3)协助对乳腺组织进行形态和组织学评估。核心实现这些目标的能力详述如下。动物核心还将作为该项目研究人员之间组织共享的协调中心。内维尔博士的经验是，必须从他们的实验室直接指派人员与动物处理核心和动物资源中心合作，生产和管理计时怀孕和哺乳期小鼠。此功能是本项目所有调查人员所必需的。此外，在动物实验中涉及到一些熟练的技术，所有的研究人员都需要一名训练有素的人员。由给定项目生成的组织可能会在其他项目中使用。协调的组织共享将促进这些跨项目的互动。

The primary objectives of this core are three fold. 1) to produce developmentally staged animals (e.g. pregnant, lactating or involuting) as needed by all investigators in this program project grant, 2) to provide mammary-specific and general surgical support, and 3) to assist in the morphological and histological evaluation of mammary tissues. The capability of the core to meet these objectives is detailed below. The animal core will also serve as a center for coordination of tissue sharing among investigators in the program project. It is the experience of Dr. Neville that personnel must be directly assigned from their laboratories to work with the Animal Handling Core and the Animal Resource Center in the production and management to timed pregnant and lactating mice. This function is required by all investigators on this program project. In addition there are some skilled techniques involved in the animal experiments for which a fully trained individual needs to be available for all investigators. Tissues generated by a given project may find use in other projects. Coordinated tissue sharing will facilitate these interactions across projects.