PDX Core

PDX核心

• 批准号: 10732949
• 负责人: Michael T. Lewis
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10732949
• 关键词: Animals; Bioinformatics; Breast; Breast Cancer therapy; Characteristics; Collaborations; Collection; Communities; Core Facility; Data; Data Analyses; Data Commons; Data Display; Development; Drug resistance; Goals; Grant; Growth and Development function; Human; Infrastructure; Institution; Joints; Logistics; Maintenance; Malignant Neoplasms; Medicine; Modeling; Modification; Molecular; Mus; Organ; Patients; Pharmaceutical Preparations; Pharmacotherapy; Pilot Projects; Population Heterogeneity; Procedures; Quality Control; Reproducibility; Research; Research Institute; Research Project Grants; Resources; Sampling; Site; Testing; Texas; Therapeutic; Tissue Sample; anticancer research; cancer prevention; cancer subtypes; college; cost effective; data exchange; ethnic diversity; in vivo Model; individual patient; malignant breast neoplasm; pathogen; patient derived xenograft model; preclinical trial; programs; racial diversity; refractory cancer; repository; response; standard of care; success; technology development; treatment response; tumor

PDX CORE PROJECT SUMMARY The goals of the PDTC PDX Core are to establish and maintain PDX lines for the purpose of conducting animal preclinical trials using experimental and standard-of-care therapeutics; to promote quality control, reproducibility, and collaboration by developing and maintaining shared Standard Operating Procedures (SOPs) for PDX development, maintenance, experimentation, and pathogen testing; to provide infrastructure to manage large PDX collections and to generate, store, and manage PDX-based experimental data generated by the projects; to facilitate exchange of PDX models between the PDXNet program; and to facilitate transfer of experimental data to the PDTC Bioinformatics Core and the PDTC PDXNet Data Commons and Coordinating Center to relate treatment responses to the molecular characteristics of individual patients’ tumors. Our PDTC PDX Core current comprises 262 breast PDX lines available for projects within our PDTC Center and across the PDXNet program.

PDX核心项目总结 PDTC PDX核心的目标是建立和维护用于引导动物的PDX线路 使用试验性和护理标准疗法的临床前试验；促进质量控制、重复性、 通过开发和维护PDX的共享标准操作程序(SOP)实现协作 开发、维护、实验和病原体测试；提供管理大型PDX的基础设施 收集并生成、存储和管理由项目生成的基于PDX的实验数据； 促进PDXNet程序之间的PDX模型的交换；并促进实验数据的传输 与PDTC生物信息学核心和PDTC PDXNet数据共享和协调中心建立联系 治疗对个体患者肿瘤的分子特征的反应。我们的PDTC PDX核心电流 包括262条乳房PDX线，可用于我们PDTC中心内和整个PDXNet计划中的项目。