GENERAL CLINICAL RESEARCH CENTER-PEDIATRIC SATELLITE

乔治城大学医学中心多年来一直是大量转化和以患者为导向的研究的所在地。在过去，著名的教授，如Proctor Harvey教授（心脏病学）和George Schreiner教授（肾脏病学）是各自领域的国际领导者。在过去的十年里，乔治敦大学在实验室和以病人为导向的研究方面做出了重大的机构承诺，在此期间，实验室空间扩大了四倍，许多研究项目的发展反映在这一申请中，并将主要医院的一层楼奉献给临床研究。与此同时，校外研究经费增加了三倍，1998财政年度的校外研究经费达到1亿美元。外部支持稳步增加，实验室研究和面向患者的研究的资金平衡。1989年，临床研究中心以现在的形式开放。从那时起，活动水平、对以患者为导向的研究的同行评审支持以及研究结果的发表也在稳步增长，这在过去四年中尤为明显。在癌症治疗、高血压、衰老、海湾战争综合征、艾滋病和药物安全等方面的优秀项目是结直肠癌研究的新方向。每一个项目都受到乔治敦国际公认的生物伦理学机构项目的影响。以临床研究中心为中心的以患者为导向的研究的临界质量使得许多研究培训和教育活动的发展成为可能，这些活动包括学生、住院医生、临床研究员和初级教师的努力。这与资助的临床药理学和肿瘤生物学研究培训项目以及其他培训项目协同发展，这些培训项目正在成为资金竞争的对象。有了高质量的同行评议研究，坚定的机构承诺，以及我们在以患者为导向的研究中继续发展的愿望，我们相信下一个合乎逻辑的步骤是建立一个得到认可和资助的普通临床研究中心。在审查此申请期间，我们期待有机会展示我们在乔治城大学医学中心开展出色的以患者为导向的研究的能力。

Georgetown University Medical Center has been a locus of substantial translational and patient-oriented research for many years. In the past notable faculty such as Professor Proctor Harvey (cardiology) and Professor George Schreiner (nephrology) were international leaders in their respective areas. Over the past decade Georgetown has made a major institutional commitment to development of both laboratory-based and patient-oriented research manifested by a quadrupling of laboratory space during that time, development of a number of research programs reflected in this application, and dedication of one floor of the Main Hospital to clinical research. His has been paralleled by a three-fold increase in extramural research funding, with extramural support in fiscal year 1998 reaching 100 million dollars. Extramural support has risen steadily, with funding balanced evenly between laboratory based and patient-oriented research. In 1989 the Clinical Research Center in its present incarnation was opened. Since that time, the level of activity, peer-reviewed support for patient-oriented research, and publication of findings have also been on a steady increase, and this has been particularly evident in the past four years. Novel aspects of CRC research are the excellent programs in cancer therapy, hypertension, aging, Gulf War Syndrome, AIDS and drug safety. Each of these programs is influenced by Georgetown's internationally recognized institutional programs in bioethics. This critical mass of patient-oriented research centered in a Clinical Research Center setting has allowed development of a number of research training and education activities which include efforts at the student, resident, clinical research fellow, and junior faculty levels. This has developed in synergy with funded research training programs in clinical pharmacology and tumor biology, and other training programs that are becoming competitive for funding. With this level of high quality peer-reviewed research, the strong institutional commitment, and the desire to continue our growth in patient-oriented research, we believe the next logical step is a recognized and funded General Clinical Research Center. During the review of this application we look forward to the opportunity to demonstrate our capability in conducting outstanding patient-oriented research at Georgetown University Medical Center.