GENERAL CLINICAL RESEARCH CENTER

乔治城大学医学中心多年来一直是大量翻译和以患者为导向的研究的中心。在过去，著名的教师，如教授普罗克特哈维（心脏病学）和教授乔治施赖纳（肾脏病学）是在各自领域的国际领导者。在过去的十年中，乔治城大学做出了重大的机构承诺，致力于发展以实验室为基础和以患者为导向的研究，这一承诺体现在实验室空间在那段时间内翻了两番，开发了一些反映在本申请中的研究项目，并将主医院的一层楼用于临床研究。1998财政年度，美国的校外研究经费达到1亿美元，比1998财政年度增加了3倍。校外支持稳步上升，资金平衡之间的实验室为基础的和面向病人的研究。1989年，临床研究中心成立。从那时起，活动水平，同行评审对以患者为导向的研究的支持，以及研究结果的出版也一直在稳步增长，这在过去四年中尤为明显。CRC研究的新方面是癌症治疗、高血压、衰老、海湾战争综合征、艾滋病和药物安全性方面的优秀项目。每一个项目都受到乔治城国际公认的生物伦理学机构项目的影响。以临床研究中心为中心的以患者为导向的研究的临界质量允许开发一些研究培训和教育活动，其中包括学生，住院医师，临床研究员和初级教师水平的努力。这与临床药理学和肿瘤生物学的资助研究培训计划以及其他正在竞争资金的培训计划协同发展。有了这种高质量的同行评审研究水平，强大的机构承诺，以及继续我们在以患者为导向的研究中增长的愿望，我们相信下一个合乎逻辑的步骤是一个公认的和资助的综合临床研究中心。在此应用程序的审查，我们期待着有机会展示我们在乔治敦大学医学中心进行优秀的以病人为导向的研究能力。

Georgetown University Medical Center has been a locus of substantial translational and patient-oriented research for many years. In the past notable faculty such as Professor Proctor Harvey (cardiology) and Professor George Schreiner (nephrology) were international leaders in their respective areas. Over the past decade Georgetown has made a major institutional commitment to development of both laboratory-based and patient-oriented research manifested by a quadrupling of laboratory space during that time, development of a number of research programs reflected in this application, and dedication of one floor of the Main Hospital to clinical research. His has been paralleled by a three-fold increase in extramural research funding, with extramural support in fiscal year 1998 reaching 100 million dollars. Extramural support has risen steadily, with funding balanced evenly between laboratory based and patient-oriented research. In 1989 the Clinical Research Center in its present incarnation was opened. Since that time, the level of activity, peer-reviewed support for patient-oriented research, and publication of findings have also been on a steady increase, and this has been particularly evident in the past four years. Novel aspects of CRC research are the excellent programs in cancer therapy, hypertension, aging, Gulf War Syndrome, AIDS and drug safety. Each of these programs is influenced by Georgetown's internationally recognized institutional programs in bioethics. This critical mass of patient-oriented research centered in a Clinical Research Center setting has allowed development of a number of research training and education activities which include efforts at the student, resident, clinical research fellow, and junior faculty levels. This has developed in synergy with funded research training programs in clinical pharmacology and tumor biology, and other training programs that are becoming competitive for funding. With this level of high quality peer-reviewed research, the strong institutional commitment, and the desire to continue our growth in patient-oriented research, we believe the next logical step is a recognized and funded General Clinical Research Center. During the review of this application we look forward to the opportunity to demonstrate our capability in conducting outstanding patient-oriented research at Georgetown University Medical Center.