GENERAL CLINICAL RESEARCH CENTER

多年来，乔治城大学医学中心一直是以患者为导向的实质性翻译研究的中心。在过去，著名的教授，如普罗克托·哈维教授(心脏病学)和乔治·施莱纳教授(肾脏科)，是各自领域的国际领导者。在过去的十年里，乔治敦大学做出了重大的机构承诺，致力于发展以实验室为基础的研究和以患者为导向的研究，具体表现为在此期间实验室空间翻了两番，开发了许多研究项目，并将主医院的一层楼用于临床研究。与他并驾齐驱的是，校外研究经费增加了三倍，1998财政年度的校外资助达到1亿美元。外部支持稳步增加，实验室研究和以患者为导向的研究资金平衡。1989年，现在的临床研究中心成立了。从那时起，活动水平、同行审查对以患者为导向的研究的支持以及研究结果的发表也在稳步增加，这在过去四年中尤为明显。CRC研究的新方面是在癌症治疗、高血压、老龄化、海湾战争综合症、艾滋病和药物安全方面的优秀项目。这些项目中的每一个都受到乔治敦大学国际公认的生物伦理学机构项目的影响。以临床研究中心为中心的大量以患者为中心的研究使许多研究培训和教育活动得以开展，其中包括在学生、住院医生、临床研究员和初级教员层面的努力。这与临床药理学和肿瘤生物学方面的资助研究培训计划以及其他正在变得具有资金竞争力的培训计划协同发展。有了这种水平的高质量同行评议研究，强大的机构承诺，以及在以患者为导向的研究中继续增长的愿望，我们相信下一步合乎逻辑的步骤是建立一个得到认可和资助的综合临床研究中心。在审查这份申请期间，我们期待着有机会展示我们在乔治敦大学医学中心进行杰出的以患者为中心的研究的能力。

Georgetown University Medical Center has been a locus of substantial translational and patient-oriented research for many years. In the past notable faculty such as Professor Proctor Harvey (cardiology) and Professor George Schreiner (nephrology) were international leaders in their respective areas. Over the past decade Georgetown has made a major institutional commitment to development of both laboratory-based and patient-oriented research manifested by a quadrupling of laboratory space during that time, development of a number of research programs reflected in this application, and dedication of one floor of the Main Hospital to clinical research. His has been paralleled by a three-fold increase in extramural research funding, with extramural support in fiscal year 1998 reaching 100 million dollars. Extramural support has risen steadily, with funding balanced evenly between laboratory based and patient-oriented research. In 1989 the Clinical Research Center in its present incarnation was opened. Since that time, the level of activity, peer-reviewed support for patient-oriented research, and publication of findings have also been on a steady increase, and this has been particularly evident in the past four years. Novel aspects of CRC research are the excellent programs in cancer therapy, hypertension, aging, Gulf War Syndrome, AIDS and drug safety. Each of these programs is influenced by Georgetown's internationally recognized institutional programs in bioethics. This critical mass of patient-oriented research centered in a Clinical Research Center setting has allowed development of a number of research training and education activities which include efforts at the student, resident, clinical research fellow, and junior faculty levels. This has developed in synergy with funded research training programs in clinical pharmacology and tumor biology, and other training programs that are becoming competitive for funding. With this level of high quality peer-reviewed research, the strong institutional commitment, and the desire to continue our growth in patient-oriented research, we believe the next logical step is a recognized and funded General Clinical Research Center. During the review of this application we look forward to the opportunity to demonstrate our capability in conducting outstanding patient-oriented research at Georgetown University Medical Center.