Development of a Maskless Array Synthesizer

描述(申请人提供)：NimbleGen将完善其专有技术 技术和制造系统融入无掩模阵列综合器系统 (MAS系统)。MAS系统将允许车主快速生产廉价的 高密度定制DNA阵列(CDA)在他们自己的设施中 规格。 NimbleGen使用光沉积化学技术构建其阵列 专有的无遮罩紫外线投影仪。德州仪器数码灯 处理器(DLP)是NimbleGen投影仪的核心。DLP雇佣了一名 微型铝镜固态阵列，图案高达780,000个 光的单个像素。下一代系统将生产高达1.3 百万像素的光线。计算机控制的制造过程要求 一旦玻璃基板被放入NimbleGen，就没有人与之互动 专有的反应室。组装在内部逐个碱基进行 反应室，消除了对其他设备常见的洁净室的需要 阵列生产工艺。通过使用无遮罩UV投影仪控制 NimbleGen在反应室中的玻璃上对紫外线进行图案化处理，实现了 无与伦比的精确度和对CDA制造的控制。MAS技术 还允许无与伦比的速度-循环时间不到四个小时-在 生产CDA，从而大大减少了开发时间和成本。 建议的商业应用： 显然需要一种廉价、快速和可靠的方法来生成和 分析定制的DNA阵列。有强烈的迹象表明，拟议的项目 商业化潜力如下：DNA阵列和DNA阵列市场 2001年制造设备预计为3.18亿美元，2001年增长到17亿美元。 2005年，年复合增长率为49%。

DESCRIPTION (provided by applicant): NimbleGen will refine its proprietary technology and manufacturing system into the Maskless Array Synthesizer System (MAS Systems). The MAS System will permit owners to rapidly produce inexpensive High Density Custom DNA Arrays (CDAs) in their own facilities to their own specifications. NimbleGen builds its arrays using photo deposition chemistry with its proprietary Maskless UV Light Projector. Texas Instruments Digital Light Processor (DLP) is at the heart of the NimbleGen Projector. The DLP employs a solid-state array of miniaturized aluminum mirrors to pattern up to 780,000 individual pixels of light. Next generation systems will produce up to 1.3 million pixels of light. The computer controlled fabricatoin process requires no human interaction once the glass substrate is placed into NimbleGen's proprietary reaction chamber. Fabrication occurs base-by-base inside the reaction chamber, eliminating the need for the clean rooms common to other array production processes. By using the Maskless UV Projector to control the patterning of UV light on the glass in the reaction chamber, NimbleGen achieves unparalleled precision and control over CDA fabrication. The MAS technology also permits unsurpassed speed - a cycle time of less than four hours - in the production of CDAs, thereby substantially reducing development time and costs. PROPOSED COMMERCIAL APPLICATION: There is a clear need for an inexpensive, rapid, and reliable method of generating and analyzing custom DNA arrays. There are strong indiciations of the proposed project's potential for commercialization, as follows: The market for DNA arrays and DNA array fabrication equipment is projected to be $318 million in 2001, growing to $1.7 billion in 2005, a CAGR of 49%.