STFC/NERC Bioinformatics & Environmental 'Omics Network

基因组学革命的广泛影响已经延伸到生物学的方方面面。作为分子研究新技术的结果，现在更好地描述了基因组的组成以及基因组和有机体对环境的反应之间存在的各种组织层。这些被称为组学(例如基因组学、转录组学、蛋白质组学、代谢组学等)的组织层现在可以访问以进行整体研究。这一调查范围不仅为更全面地了解生物体或群落如何与环境相互作用提供了无与伦比的机会，而且还创造了环境生物学中前所未有的信息学挑战。随着仪器技术的进步，组学研究产生的绝对数据量比环境生物学中的标准高出几个数量级，这给数据存储、数据分析乃至数据结构的整体优化带来了新的挑战。与此同时，生物信息学和环境组学的有效结合可以为解决关键问题的创新创造重要的新机会。为了充分利用这些发展的潜力来实现其战略--“地球的下一代科学”，国家环境研究中心建立了一个虚拟的环境“有机合成中心”，以促进环境“组学”的新科学方法的结合和出现。EOS的任务是在NERC社区内实现可能受益于环境组学并为其发展做出贡献的新颖科学合成。STFC拥有完善的基础设施，可以处理未来环境组学研究可能产生的规模的复杂数据。因此，在国家环境研究中心确定的对环境组学的生物信息学方法的扩大规模的新需求与科学、技术和创新中心现有的设施基础之间，对双方都有很大的协同潜力。目前的科学、技术和创新中心全球网络呼吁，为发展科学、技术和创新中心与环境科学研究中心在环境科学方面的密切联系提供了一个及时的机会。事实上，第二届STFC环境未来研讨会(http://www.stfc.ac.uk/resources/pdf/FuturesEnv2Report.pdf).特别强调了环境组学带来的生物信息学挑战NERC EOS刚刚建立，因此，在现阶段与STFC科学家建立网络将确保STFC的广泛资源基础将成为生物信息学和环境组学的重要组成部分，因为这些领域之间的合作将在未来五年内发展。我们计划每年举办两次研讨会，每一次都针对STFC和NERC之间预期具有协同潜力的有针对性的研究领域。首先，探索STFC和NERC联合开发生物信息学和环境‘组学潜力的指示性研讨会主题包括：a)新的数据结构、新的算法和本体。环境组学提出的生物信息学挑战得到了广泛的认可，但这些挑战的详细性质和应对这些挑战的有效方法都需要进一步发展。B)将环境经济学与其他大规模数据结构和模型联系起来，例如涉及气候和其他主要环境循环的数据结构和模型。c)环境生物过程和人类健康之间的相互作用，例如环境毒理学和环境污染，因为它们是威胁健康的抗菌剂耐药性的一个来源。d)模拟基本生态系统服务及其对环境变化的复原力所依赖的复杂生物相互作用。

The widespread impact of the genomics revolution has reached into every aspect of biology. As a result of new technologies for molecular investigation, the composition of the genome and the various organisational layers that exist between the genome and organismic response to the environment are now better described. These organisational layers, known as 'omics (e.g., genomics, transcriptomics, proteomics, metabolomics, etc), are now accessible for investigation in their entirety. This scope of investigation has not only opened unparalleled opportunities for a more complete understanding of how organisms or communities interact with the environment but also created an informatics challenge unprecedented in environmental biology. With technical advances in instrumentation, the sheer volume of data generated by 'omics investigation is orders of magnitude higher that has been the norm in environmental biology, creating new challenges for data storage, data analysis, and indeed optimisation of data structures generally. At the same time, important new opportunities for innovation in addressing critical problems can arise from the effective blending of bioinformatics and environmental 'omics. To leverage the full potential of these developments to deliver its strategy, 'Next Generation Science for Planet Earth', the NERC has established a virtual Environmental 'Omics Synthesis Centre to facilitate the coalescence and emergence of novel scientific approaches to environmental 'omics. EOS is tasked with enabling the emergence of novel scientific synthesis within the NERC community that might benefit from environmental 'omics as well as contribute to its development. STFC has a well-established infrastructure for addressing complex data on the scale that is likely to be generated through future investigations in environmental 'omics. Therefore there is substantial potential for synergism between the emerging need for enhanced scale of bioinformatics approaches to environmental 'omics as indentified by the NERC and the existing facilities base in the STFC, to the benefit of both.The present STFC Global Networks call provides a timely opportunity for the development of strong connections between STFC and NERC interests in environmental sciences. Indeed, the bioinformatics challenge presented by environmental 'omics was specifically highlighted at the second STFC Environment Futures Workshop (http://www.stfc.ac.uk/resources/pdf/FuturesEnv2Report.pdf). The NERC EOS is just now being established, so that network building with STFC scientists at this stage will ensure that the extensive resource base of the STFC will be an integral part of bioinformatics and environmental 'omics as collaboration between these fields is developed over the next five years.We plan to conduct two workshops per year, addressing in each case targeted research areas where there is anticipated potential for synergy between STFC and NERC. At the outset, indicative workshop themes for exploring joint STFC and NERC development of the potential of bioinformatics and environmental 'omics include:a) Novel data structures, novel algorithms and ontologies. The bioinformatics challenges raised by environmental 'omics are widely recognised, but both the detailed nature of these challenges and effective approaches for addressing them require further development. b) Linking environmental 'omics to other large scale data structures and models, for example those involving climate and other major environmental cycles.c) The interplay between environmental biological processes and human health, for example environmental toxicology and environmental pollution as a source of health-threatening antimicrobial resistance.d) Modelling complex biological interactions underlying basic ecosystem services and their resilience to environmental change.