Point-of-Care Chemiluminescent Diagnostic for 'early detection'of the predisposition to Type 2 diabetes.

用于“早期检测”2 型糖尿病倾向的护理点化学发光诊断。

• 批准号: ST/K001892/1
• 负责人: Robert Stevens
• 金额: $ 6.21万
• 依托单位: Nottingham Trent University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FK001892%2F1
• 关键词: Point; Care; Chemiluminescent; Diagnostic; early

Chemically induced light emission technology is being coupled to engineered nanoscale structures to create a unique type of sensor which is so sensitive and so specific that it will be able to measure extremely low levels of disease markers in a blood sample. The molecules of interest for a proof of concept demostrator are those associated with Type 2 diabetes. The point-of-care diagnostic will allow a member of the public to determine whether they are likely to develop Type 2 Diabetic within the next 5 years of life. The user would be able to do this at home, at a pharmacist or under the supevision of their doctor. The key to the technology is the nanostructure and composition of a biosensing patch which can be produced in extremely large numbers at low cost by combining scale up techniques to make large sheets of the nanoscale material with extremely fast laser cutting processes which are able to cut channels which are only 10 micrometers wide.The technology has the potential to be configured to measure panels of disease markers within a single blood spot sample, which has the potential to measure the severity of disease and determine how far the disease has progressed.The high sensitivity and specificity of the diagnostic will allow early diagnososis of disease, which will lead to improved patient outcomes.Other applications include environmental and food monitoring and anti-counterfeit.

化学诱导光发射技术正在与工程纳米结构相结合，以创建一种独特类型的传感器，这种传感器非常敏感和特异，能够测量血液样本中极低水平的疾病标志物。用于概念验证演示器的感兴趣的分子是与2型糖尿病相关的分子。即时诊断将允许公众成员确定他们是否可能在未来5年内发展为2型糖尿病。用户可以在家里，药剂师或在医生的监督下这样做。该技术的关键是生物传感贴片的纳米结构和组成，通过将放大技术与能够切割仅10微米宽的通道的极快激光切割过程相结合，可以以低成本大量生产这种纳米级材料的大片。该技术有可能被配置为测量单个血液中的疾病标志物组。点样，有可能测量疾病的严重程度并确定疾病的进展程度。诊断的高灵敏度和特异性将允许早期诊断疾病，这将改善患者的治疗结果。其他应用包括环境和食品监测和防伪。