Early warning point of care diagnostics for type 2 diabetes

2 型糖尿病的早期预警护理点诊断

• 批准号: ST/M004244/1
• 负责人: Robert Stevens
• 金额: $ 15.05万
• 依托单位: Nottingham Trent University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FM004244%2F1
• 关键词: Early; warning; point; care; diagnostics

Chemically induced light emission technology has been coupled to engineered nanoscale structures to create a unique type of sensor which is so sensitive and so specific that it will be able to measure extremely low levels of disease markers in a blood sample. The markers of interest are those associated with Type 2 diabetes. The two diagnostic platforms will allow clinicians to determine whether a patient is likely to develop Type 2 diabetes within the next 5 years of life. Point of care diagnostic system will be developed in the future to allow a user to do this at home, at a pharmacist or under the supevision of their doctor. The key to the technology is the nanostructure and composition of the biosensing material. The academic and industrial project team will produce both a market ready well plate technology and point of care prototypes using their existing resources and know how. The technology has the potential to be configured to measure panels of disease markers within a single blood spot sample, which has the potential to measure the severity of disease and determine how far the disease has progressed.The high sensitivity and specificity of the diagnostic will allow early diagnosis of disease, which will lead to improved patient outcomes.Other applications include environmental, agriculture, food monitoring and anti-counterfeit tests.

化学诱导光发射技术已经与工程纳米结构相结合，以创建一种独特类型的传感器，这种传感器非常敏感和特异，能够测量血液样本中极低水平的疾病标志物。感兴趣的标志物是与2型糖尿病相关的标志物。这两个诊断平台将允许临床医生确定患者是否可能在未来5年内患上2型糖尿病。未来将开发护理点诊断系统，以允许用户在家中、药剂师处或在医生的监督下进行诊断。该技术的关键是生物传感材料的纳米结构和组成。学术和工业项目团队将利用其现有资源和专业知识生产市场就绪的微孔板技术和护理点原型。该技术有可能被配置为测量单个血斑样本中的疾病标志物组，这有可能测量疾病的严重程度并确定疾病的进展程度。诊断的高灵敏度和特异性将允许早期诊断疾病，这将导致改善患者的结果。其他应用包括环境，农业，食品监测和防伪测试。