AMC OPERATIONS CENTER

AMC运营中心

• 批准号: 6349673
• 负责人: Jeannette Y. Lee
• 金额: $ 52.5万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349673
• 关键词: AIDS related neoplasm /cancer; AIDS therapy; Hodgkin's disease; Internet; Kaposi's sarcoma; cancer information system; cervix neoplasms; clinical research; clinical trials; cooperative study; data collection; diagnosis quality /standard; experimental designs; human subject; human therapy evaluation; neoplasm /cancer therapy; nonHodgkin's lymphoma; rectum neoplasms; statistical service /center; statistics /biometry; tissue resource /registry

This proposal is for the Comprehensive Cancer Center Biostatistics Unit at the University of Alabama at Birmingham (UAB) to serve as the Operations, Statistical and Data Management Center for the AIDS-Associated Malignancies Clinical Trials Consortium (AMC). To date, the AMC has enrolled 159 patients on five AMC protocols. Two protocols have recently opened to patient accrual. An additional 9 protocols are under development. The AMC Operations Center provides statistical expertise to the AMC in the areas to study design, sample size, and analyses; coordinates the development, submission, conduct and analysis of AMC; maintains the database for the clinical trials; performs statistical analyses on study data; manages the Discretionary Fund; and coordinates the acquisition of specimens from AMC participants for donation to the AIDS Malignancy Bank. During the upcoming funding period, the AMC Operations Center plans to increase the use of scanners in the data entry process; increase the level of biostatistical support; increase the use of the AMC WEB page for the dissemination of information; and add a fiscal associate to the staff to manage the discretionary fund.

该提案是由阿拉巴马大学伯明翰分校（UAB）的综合癌症中心生物统计部门作为艾滋病相关恶性肿瘤临床试验联盟（AMC）的操作、统计和数据管理中心。迄今为止，AMC已根据5种AMC方案招募了159名患者。最近有两项方案向患者开放。另有9项议定书正在制定中。AMC运营中心为AMC提供研究设计、样本量和分析方面的统计专业知识；协调AMC的制定、提交、实施和分析；维护临床试验数据库；对研究数据进行统计分析；管理全权委托基金；并协调从AMC参与者那里获取标本，捐赠给艾滋病恶性肿瘤银行。在即将到来的资助期内，AMC运营中心计划在数据输入过程中增加扫描仪的使用；提高生物统计学支持水平；增加使用AMC WEB页面发布信息；并在员工中增加一名财务助理来管理自由裁量基金。