CANNABINOID RECEPTOR PHARMACOLOGY AND BIOCHEMISTRY

大麻素受体药理学和生物化学

• 批准号: 6378243
• 负责人: ALLYN C HOWLETT
• 金额: $ 11.51万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6378243
• 关键词: G protein; acylation; biological signal transduction; brain metabolism; cannabinoid receptor; cannabinoids; chemical structure function; eicosanoids; human tissue; laboratory rat; neoplastic cell culture for noncancer research; neurons; neuropharmacology; phosphorylation; posttranslational modifications; receptor binding; stimulant /agonist; tissue /cell culture

DESCRIPTION: (Applicant's Abstract) This is a Research Scientist Award for Dr. Allyn Howlett, who has a B.S. cum laude, in Biochemistry and Ph.D. in Pharmacology and Toxicology. Dr. Howlett is a tenured Professor in the Dept. Pharmacological and Physiological Science at Saint Louis University School of Medicine, a large, technically multidisciplinary department with research interests in cardiovascular, endocrine and neural physiology and pharmacology. Dr. Howlett's research effort is concentrated on the pharmacological, biochemical and cellular regulation of the CB1 cannabinoid receptor. Her intention is to maintain an active research laboratory in which students, fellows and visiting scientists can exchange ideas and share from their areas of expertise. Toward this goal, Dr. Howlett requests the continuation of this RSA in order to allow ample research time to attend to each individual working on the research project and to maintain research collaborations with other scientists. The RSA will also foster continued professional development through research meetings, short courses and communication with other research scientist. Dr. Howlett's research projects have been described in two NIDA-funded R01 grants. "Cannabinoid Receptor Structure-Activity Releationships" examines the receptor-ligand interaction (cannabinoid, aminoalkylindole, eicosanoid, and other structures) in an effort to define the requirements for high-affinity association and efficacy, such that pharmacologically distinct agonists and antagonist (CB1- or CB2-selective) can be determined or developed. This project involves close collaboration with synthetic, analytical, and computational chemist. "Cannabinoid Receptors in Neuronal Cells and Brain" addresses the mechanisms through which the receptor signals its response through G proteins, and the mechanisms whereby the cell regulates this activity through modification of the receptor (e.g., phosphorylation, palmitoylation) and regulation of synthesis, cellular localization, and degradation.

描述：（申请人摘要） 这是一个研究科学家奖博士阿林豪利特，谁拥有学士学位。暨 生物化学和哲学博士药理学和毒理学。 博士 Howlett是该系的终身教授。 药理学和 生理科学在圣刘易斯大学医学院，一个大型的， 多学科技术部门，研究领域包括 心血管、内分泌和神经生理学和药理学。 博士 豪利特的研究工作集中在药理学， CB 1大麻素受体的生物化学和细胞调节。 她 目的是维持一个活跃的研究实验室，学生， 研究员和访问科学家可以交换意见，分享他们的 专业领域。 为了实现这一目标，豪利特博士要求继续 为了让充足的研究时间来参加每一个 个人工作的研究项目，并保持研究 与其他科学家的合作。 RSA还将继续促进 通过研究会议、短期课程和 与其他研究科学家沟通。 豪利特博士的研究 项目已在NIDA资助的两项R 01赠款中进行了描述。 “大麻素 受体结构-活性关系”研究受体-配体 相互作用（大麻素、氨基烷基吲哚、类二十烷酸等 结构），以努力定义高亲和力的要求。 关联和功效，从而确定不同的激动剂和 拮抗剂（CB 1-或CB 2-选择性）可以被确定或开发。 这 该项目涉及与合成，分析和 计算化学家 “Cannabinoid Receptors in Neuronal Cells and Brain” 阐述了受体发出反应信号的机制 通过G蛋白，以及细胞调节这一点的机制， 通过修饰受体的活性（例如，磷酸化， 棕榈酰化）和合成调节，细胞定位，和 降解