A new therapeutic target for stress-related relapse

压力相关复发的新治疗靶点

• 批准号: nhmrc : 1079893
• 负责人: Prof Andrew Gundlach
• 金额: $ 45.69万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-therapeutic-target-related-relapse/518708
• 关键词: new; therapeutic; target; stress; related

Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. We have identified a novel system in the brain for the regulation of stress-induced relapse. Successful completion of this project will indicate improved pharmacotherapeutic strategies for the treatment of alcoholism and drug abuse. Given the scale and costs of substance abuse disorders, improved therapeutic approaches will have immediate and sustained impact.

复发和危险饮酒是治疗酒精使用障碍患者的最困难的临床问题。我们已经确定了大脑中一种新的系统，用于调节应激诱导的复发。该项目的成功完成将标志着治疗酒精中毒和药物滥用的药物治疗战略得到改进。考虑到药物滥用障碍的规模和成本，改进的治疗方法将产生直接和持续的影响。