Uncoupled Research Fellowship

解耦研究奖学金

• 批准号: nhmrc : 277906
• 负责人: Prof Andrew Gundlach
• 金额: $ 55.58万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Research Fellowships
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/uncoupled-research-fellowship/113675
• 关键词: Uncoupled; Research; Fellowship

I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiological and possible pathological roles of newly discovered neuropeptides and their cognate receptors in mammalian brain. My recent research has focused on the highly-conserved, abundant peptide, relaxin-3 that was discovered at the HFI in 2002. Studies so far have revealed that relaxin-3 is a powerful modulator of rhythmic brain activity (theta) and spatial memory, and alters feeding, body weight and arousal. Relaxin-3 levels in brain are also strongly activated by acute stress. In the future, I aim to elucidate further the role of relaxin-3 systems in normal physiology and metabolic and-or psychiatric diseases.

我是一名神经科学家，采用解剖学，生物化学，药理学，遗传学和行为分析的策略来研究新发现的神经肽及其同源受体在哺乳动物大脑中的生理和可能的病理作用。我最近的研究集中在高度保守，丰富的肽，松弛素-3，是在2002年发现的HFI。迄今为止的研究表明，松弛素-3是一种强有力的大脑节律活动（theta）和空间记忆的调节剂，并改变进食，体重和唤醒。大脑中的松弛素-3水平也被急性应激强烈激活。在未来，我的目标是进一步阐明松弛素-3系统在正常生理和代谢和精神疾病中的作用。