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ROCHESTER AREA PEPPER CENTER

罗切斯特地区胡椒中心

基本信息

批准号：
6168118
负责人：
WILLIAM John HALL
金额：
$ 64.37万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-09-30 至 2004-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6168118
关键词：
aging

项目摘要

The renewal of the Rochester Area Pepper Center (RAPC) builds on the experience of the previous 3 + years. The current RAPC's 2 intervention (IS) and 2 intervention development (IDS) studies focused on evaluating ways to improve or maintain the functional status of the elderly at various stages of physical dependency using standard exercise or pharmacologic interventions and pre- and post-treatment methods of functional assessment. Excellent progress has resulted in 23 publications from the IDs or IDSs, 93 from research of RAPC faculty, and 49 from work funded by the RDC. Despite past progress, the new proposal moves in a new direction. We will integrate basic mechanistic research into 3 clinical IDSs. IDS#1 extends our successful IS of Acute Respiratory Tract Infections (ARTI) in the frail elderly to determine if alterations in immunologic and thrombotic status are predisposers or contributors to, the functional decline noted in ARTI. IDS#2 builds on the current IS findings showing that resistance exercise training does not greatly improve myofibrillar protein synthesis in healthy elderly subjects. The new goal is to determine if a 'more youthful' rate of myofibrillar protein synthesis will result from gonadal steroid therapy thus minimizing the age-related skeletal muscle atrophy. In IDS#3 complementary approaches will be used to study the disease- or age-related declines in neural mechanisms governing spatial orientation and equilibrium control. These approaches include standing balance (postural control), eye-head and eye- head-hand coordination, and visual motion processing that distinguishes self- from externally -initiated movements. The goal is to clarify the parameters that maintain and influence sensory-motor integration between subject and environment. Research Development (RD), Research Resource ; [Biostatistics (RRB)], Demonstration and Information Dissemination (DID), and Administrative (LA) Cores contribute to all RAPC functions. The Cores a) provide seed money for new initiatives and to support the career development of junior faculty (RD); b) provide methods (RRA) for accurate assay of glutathione metabolism for the IDS and other ongoing research; c) assist in the experimental design and statistical analysis of data (RRB); d) inform the medical and lay communities of the RAPC's work and publicize its educational programs (DIDC); and e) provide the leadership, administrative structure and oversight (LA) needed to fulfill the goals of the IDS and Cores. The abiding principle in developing the new RAPC was that its studies and functions, relate and contribute to ongoing clinical and research programs at the U of R Medical Center thereby enhancing the Center's function and significance.

罗切斯特地区胡椒中心（RAPC）的更新建立在过去3年+的经验。当前RAPC的2个干预措施 (IS)和2项干预开发（IDS）研究，重点是评估改善或维持老年人功能状态的方法不同阶段的身体依赖使用标准锻炼或药物干预和治疗前后的方法，功能评估取得了很大进展，发表了23篇文章来自IDS或IDS，93来自RAPC教师的研究，49来自工作由RDC资助。尽管过去取得了进展，但新提案提出了一个新的方向我们将把基础机制研究纳入3个临床身份识别系统 IDS#1扩展了我们成功的急性呼吸道IS 感染（阿尔蒂），以确定是否改变免疫学和血栓形成状态是易患者或贡献者，在阿尔蒂中观察到功能下降。 IDS#2建立在当前IS调查结果的基础上表明阻力训练并不能大大改善健康老年人的肌原纤维蛋白合成。新目标是为了确定肌原纤维蛋白的“更年轻”率是否合成将由性腺类固醇治疗引起，从而最小化与年龄相关的骨骼肌萎缩在IDS#3补充方法中，将被用于研究疾病或年龄相关的神经功能衰退，空间定位和平衡控制机制。这些方法包括站立平衡（姿势控制），眼-头和眼- 头手协调，以及视觉运动处理，从外部发起的运动。目标是澄清维持和影响感觉运动整合的参数，主题和环境。研究开发（RD），研究资源; [生物统计学（RRB）]，示范和信息传播（DID），和行政（LA）核心有助于所有RAPC功能。核 a）为新倡议提供种子资金，并支持职业生涯初级教师的发展（RD）; B）提供准确的方法（RRA）用于IDS和其他正在进行的研究的谷胱甘肽代谢测定; c）协助实验设计和数据统计分析（RRB）; （d）向医疗界和非专业人士介绍RAPC的工作，其教育计划（DIDC）;和e）提供领导，行政结构和监督（LA）需要实现的目标， IDS和核心。开发新的RAPC的不变原则是它的研究和功能，涉及并有助于正在进行的临床在R医学中心的U研究项目，从而提高中心的功能和意义。