TUMOR CLASSIFICATION BY LESION GEOMETRY

按病变几何形状进行肿瘤分类

• 批准号: 6349317
• 负责人: PHILIP D BERGEY
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349317
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biomedical resource; magnetic resonance imaging; technology /technique

Variations in tissue properties relating to mechanical stiffness have clinical relevance. Physiologic progressions of growth such as fetal lung development may be monitored, or pathologic changes such as infarction or malignancy may be detected with an appropriate method of observing tissue elasticity. We have investigated magnetic resonance techniques for visualizing and quantizing tissue elastic properties. In particular, we have compared and contrasted phase-contrast magnetic resonance methods which include static, steady-state, and transient elasticity experiments. Using finite element computer techniques, experimental models are generated and their behaviors simulated. Particular experiments have then been implemented for experimental verification on agarose and ex-vivo samples. A publication has accepted which synthesizes the theory, modeling, and experimental techniques as described. This work also includes practical technical details of the technique including a method of two-dimensional phase-unwrapping, and the engineering of a novel probe design for magnetic resonance elastography which has advantages over other existing implementation available in current literature.

与机械刚度相关的组织特性变化 具有临床意义。 生长的生理过程，如 可以监测胎儿肺发育，或病理变化， 梗塞或恶性肿瘤可以用适当的方法检测， 观察组织弹性。 我们研究了磁共振 用于可视化和量化组织弹性特性的技术。 特别是，我们比较和对比了相位衬度磁 谐振方法，包括静态、稳态和瞬态 弹性实验 利用有限元计算机技术， 生成实验模型并模拟它们的行为。 然后实施了特定的实验以进行实验性研究。 琼脂糖和离体样品的验证。 出版物有 它综合了理论、建模和实验 技术如所述。 这项工作还包括实际的技术 技术细节包括 一种二维相位展开的方法， 一种用于磁共振弹性成像的新型探头设计， 优于当前可用的其他现有实现的优点 文学