MRI OF DIAPHRAGM ROLE IN SCREENING CANDIDATES FOR LUNG VOLUME REDUCTION SURGERY

MRI 检查膈肌在筛选肺减容手术候选者中的作用

• 批准号: 6495479
• 负责人: PHILIP D BERGEY
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495479
• 关键词: biomedical resource; clinical research; clinical trials; female; human subject; musculoskeletal system; physical fitness; women's health

The purpose of this study is to 1) compare glycolytic muscle metabolism in patients with chronic fatigue syndrome (CFS) with normal humans, 2) test the feasibility of using near-infrared spectroscopy (NIRS) measurements to evaluate patients with chronic fatigue syndrome, and 3) to determine if exercise training improves muscle metabolism in CFS patients. To address these aims we tested 27 subjects controls and patients with CFS as identified by Dr. Natelson's research group. The medial gastrocnemius was studied and repeated plantar flexions were performed using a isokinetic device. CFS subjects had oxidative capacity (Vmax determined from PCr recovery) compared to control subjects, consistent with our previous studies. Seven of the 21 CFS patients had abnormal rates of H+ production during the 64 s maximal test. Three had slower H+ rates and four had faster H+ rates. NIRS measurements of the rate of oxygen resaturation showed close agreement with PCr recovery rates in control subjects (32.5 + 11 for NIRS compared to 29.9 + 4.8 s for PCr). However, NIRS recovery after exercise was slower the CFS patients than PCr recovery (48.2 + 21 for NIRS compared to 35.4 + 14 s for PCr). In addition, NIRS recovery of oxygen saturation was slower after cuff ischemia in CFS patients compared to controls (20.8 + 13 for CFS compared to 11.3 + 2.8 s for controls). Four CFS subjects have completed the training and testing protocol. Future studies will continue to test CFS patients and control subjects to complete our aims. We plan to continue testing of CFS patients and normal subjects who are enrolling in the exercise program. We also plan to follow up the NIRS findings of reduced oxygen delivery by measuring muscle blood flow in CFS patients with alternative means (Duplex Doppler flow measurements). In one CFS patient with slow NIRS recovery, Doppler measures showed normal peak blood flows, but reduced sensitivity to submaximal hyperemic stimuli.

本研究的目的是：1)比较糖酵解肌肉 慢性疲劳综合征(CFS)患者的代谢 人类，2)测试使用近红外光谱技术的可行性 近红外光谱(NIRS)测量用于评估慢性疲劳患者 综合症，以及3)确定运动训练是否改善肌肉 慢性疲劳综合征患者的代谢。为了实现这些目标，我们测试了27个 受试者、对照组和被确认为CFS患者。 纳特尔森的研究小组。对腓肠肌内侧支进行了研究。 使用等速装置进行重复的足底屈曲。 CFS受试者具有氧化能力(通过聚合酶链式反应测定Vmax 恢复)与对照受试者相比，与我们之前的 学习。21例CFS患者中有7例H+异常率 出品期间对S进行了最大考验。三个人的H+比率较低 其中四个人的H+速率更快。氧含量的近红外光谱测量 重饱和度显示与PCR回收率非常一致 对照组(32.5+11，S 29.9+4.8 聚合酶链式反应。然而，运动后的近红外光谱恢复慢于CFS 患者较聚合酶链式反应恢复(48.2nIRS+21vs35.4%14)S 用于聚合酶链式反应)。此外，近红外光谱对血氧饱和度的恢复较慢 CFS患者袖带缺血后与对照组比较(20.8±13 CFS组为11.3±2.8%(对照组为S)。四名CFS受试者 已经完成了培训和测试方案。未来的研究将 继续测试CFS患者和对照受试者以完成我们的 目标。我们计划继续测试CFS患者和正常受试者 正在参加锻炼计划的人。我们还计划跟进 肌肉血氧输送减少的近红外光谱研究 不同方法治疗的慢性疲劳综合征患者的血流(双功多普勒血流) 测量)。1例慢性疲劳综合征患者近红外光谱恢复缓慢， 测量结果显示峰值血流正常，但对 次最大充血刺激。