MRI OF DIAPHRAGM ROLE IN SCREENING CANDIDATES FOR LUNG VOLUME REDUCTION SURGERY

本研究的目的是1）比较糖酵解肌 慢性疲劳综合征（CFS）患者的代谢正常 人类，2）测试使用近红外光谱的可行性 （NIRS）测量，以评估慢性疲劳患者 综合征，以及3）确定运动训练是否改善肌肉 CFS患者的代谢。 为了实现这些目标，我们测试了27个 受试者、对照组和CFS患者（由Dr. 纳特森的研究小组。 对内侧腓肠肌进行了研究， 使用等速装置进行重复的足底屈曲。 CFS受试者的氧化能力（Vmax由PCr测定 恢复）与对照组相比，与我们以前的研究结果一致。 问题研究 21例CFS患者中有7例H+检出率异常 在64 s最大测试期间生产。 三个有较慢的H+率 四个有更快的H+速率。 NIRS测量氧的速率 再饱和与PCr恢复率密切相关， 对照组受试者（NIRS为32.5 ± 11，而NIRS为29.9 ± 4.8 s） PCr）。 然而，运动后NIRS恢复较慢，CFS PCr恢复的患者（NIRS为48.2 ± 21，NIRS为35.4 ± 14 PCr）。 此外，近红外光谱血氧饱和度恢复较慢 与对照组相比，CFS患者在袖带缺血后（20.8 ± 13 CFS为11.3 ± 2.8 s，对照组为11.3 ± 2.8 s）。 4个CFS科目 已经完成了培训和测试协议。 未来的研究将 继续测试CFS患者和对照受试者， 目标。 我们计划继续对CFS患者和正常受试者进行测试 参加锻炼计划的人 我们还计划跟进 通过测量肌肉血液减少氧气输送的NIRS结果 CFS患者采用替代方法（双功多普勒血流 测量）。 在1例近红外光谱恢复缓慢的CFS患者中，多普勒 测量显示正常的峰值血流量，但对 次最大充血刺激。

The purpose of this study is to 1) compare glycolytic muscle metabolism in patients with chronic fatigue syndrome (CFS) with normal humans, 2) test the feasibility of using near-infrared spectroscopy (NIRS) measurements to evaluate patients with chronic fatigue syndrome, and 3) to determine if exercise training improves muscle metabolism in CFS patients. To address these aims we tested 27 subjects controls and patients with CFS as identified by Dr. Natelson's research group. The medial gastrocnemius was studied and repeated plantar flexions were performed using a isokinetic device. CFS subjects had oxidative capacity (Vmax determined from PCr recovery) compared to control subjects, consistent with our previous studies. Seven of the 21 CFS patients had abnormal rates of H+ production during the 64 s maximal test. Three had slower H+ rates and four had faster H+ rates. NIRS measurements of the rate of oxygen resaturation showed close agreement with PCr recovery rates in control subjects (32.5 + 11 for NIRS compared to 29.9 + 4.8 s for PCr). However, NIRS recovery after exercise was slower the CFS patients than PCr recovery (48.2 + 21 for NIRS compared to 35.4 + 14 s for PCr). In addition, NIRS recovery of oxygen saturation was slower after cuff ischemia in CFS patients compared to controls (20.8 + 13 for CFS compared to 11.3 + 2.8 s for controls). Four CFS subjects have completed the training and testing protocol. Future studies will continue to test CFS patients and control subjects to complete our aims. We plan to continue testing of CFS patients and normal subjects who are enrolling in the exercise program. We also plan to follow up the NIRS findings of reduced oxygen delivery by measuring muscle blood flow in CFS patients with alternative means (Duplex Doppler flow measurements). In one CFS patient with slow NIRS recovery, Doppler measures showed normal peak blood flows, but reduced sensitivity to submaximal hyperemic stimuli.