TUMOR CLASSIFICATION BY LESION GEOMETRY

按病变几何形状进行肿瘤分类

• 批准号: 6657651
• 负责人: PHILIP D BERGEY
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657651
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biomedical resource; magnetic resonance imaging; technology /technique

Variations in tissue properties relating to mechanical stiffness have clinical relevance. Physiologic progressions of growth such as fetal lung development may be monitored, or pathologic changes such as infarction or malignancy may be detected with an appropriate method of observing tissue elasticity. We have investigated magnetic resonance techniques for visualizing and quantizing tissue elastic properties. In particular, we have compared and contrasted phase-contrast magnetic resonance methods which include static, steady-state, and transient elasticity experiments. Using finite element computer techniques, experimental models are generated and their behaviors simulated. Particular experiments have then been implemented for experimental verification on agarose and ex-vivo samples. A publication has accepted which synthesizes the theory, modeling, and experimental techniques as described. This work also includes practical technical details of the technique including a method of two-dimensional phase-unwrapping, and the engineering of a novel probe design for magnetic resonance elastography which has advantages over other existing implementation available in current literature.

与机械硬度有关的组织特性的变化 有临床意义。生长的生理进程，如 可监测胎儿肺发育，或病理变化，如 可以用适当的方法检测到梗塞或恶性肿瘤。 观察组织弹性。我们已经研究了磁共振 可视化和量化组织弹性特性的技术。 特别是，我们对相衬磁性进行了比较和对比 包括静态、稳态和暂态的谐振方法 弹性实验。使用有限元计算机技术， 生成了实验模型，并对其行为进行了模拟。 然后，对实验进行了特定的实验 琼脂糖凝胶和体外样品的验证。一份出版物有 它综合了理论、模型和实验 所描述的技术。这项工作还包括实用的技术 这项技术的细节包括 一种二维位相展开方法及其工程实现 一种用于磁共振弹性成像的新型探头设计 与当前提供的其他现有实施相比具有优势 文学。