IMPROVEMENTS IN RAPID MIX FLOW CELL DESIGN FOR SUB MILLISECOND PROTEIN FOLDING

骨质疏松症是一种以骨量减少为特征的疾病， 导致了一具脆弱的骨骼。很明显，骨质流失发生在 这种疾病；然而，在发病后骨质量重塑 这种病是未知的。我们用的是同步加速器红外线 显微光谱分析骨的化学成分 在骨质疏松症发作之前和之后进行了重塑。在我们的 研究发现，雌性食蟹猴被摘除卵巢或 假卵巢摘除。卵巢切除后，许多猴子长出了 骨质疏松。手术后，给猴子们注射了 在尸检前的两年里，每六个月服用一次荧光药物。 这些荧光染料(四环素、钙黄绿素和二甲酚橙)是 移植到新改建的骨组织中。因此，通过组合 荧光显微镜和红外显微光谱，我们能够 识别和比较新骨和旧骨的化学成分 祝你幸福。我们正在检查矿物/基质的比例，矿物 组成，以及作为骨龄函数的基质组成。

Osteoporosis is a disease characterized by reduction in bone mass, resulting in a fragile skeleton. It is clear that bone loss occurs in the disease; however, the quality of bone remodeled after the onset of Hthe disease is unknown. We are using synchrotron infrared microspectroscopy to analyze the chemical composition of bone remodeled before versus after the onset of osteoporosis. In our study, female cynomolgus monkeys were ovariectomized or sham-ovariectomized. After ovariectomization, many monkeys developed osteoporosis. After surgery, the monkeys were administered fluorescent drugs every six months for two years prior to necropsy. These fluorochromes (tetracycline, calcein, and xylenol orange) are taken into newly remodeled bone tissue. Thus, by combining fluorescence microscopy and infrared microspectroscopy, we are able to identify and compare the chemical composition of new versus older bone Hgrowth. We are examining the mineral/matrix ratios, mineral composition, and matrix composition as a function of bone age.