MEMBRANE BOUND TRYPTOPHAN DYNAMICS IN CECROPIN

天蚕素中的膜结合色氨酸动力学

• 批准号: 6328054
• 负责人: Paul H Axelsen
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6328054
• 关键词: biological products; biomedical resource; proteins

Cecropin A is a naturally occurring linear antimicrobial peptide produced by insect larvae; it has potent antimicrobial activity and comprises what appears to be the sole host defense against bacterial infection in these organisms. As part of an array of biophysical investigations into the mechanism by which these peptides accomplish their antimicrobial effect, we are characterizing the rotational activity of the single Trp residue in both free and membrane-bound forms of cecropin A using time-resolved anisotropy measurements of the Trp side chain fluorescence.

天蚕素A是一种天然存在的线性抗菌肽