TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917

CP-263、114 和 CP-225、917 的全合成

• 批准号: 6342044
• 负责人: GARY ALLEN SULIKOWSKI
• 金额: $ 15.28万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342044
• 关键词: Fungi; alkyltransferase; biological products; chemical addition; cyclization; drug design /synthesis /production; enzyme inhibitors; farnesyl compound; heterocyclic compounds; squalene

Two structurally unique compounds, CP-263,114 and CP-225,917, were recently isolated from an unidentified fungus while screening for squalene synthase inhibitors. These natural products were found to inhibit ras farnesyl transferase. One objective of this grant application is to develop a practical and efficient total synthesis of CP-263,114 and CP-225,917 which will allow the production of modified versions of these inhibitors for evaluation against ras farnesyl transferase and squalene synthase.

2个结构独特的化合物，CP-263,114和CP-225,917， 最近从一种不明真菌中分离出来，当时正在筛选 角鲨烯合成酶抑制剂。这些天然产品被发现 抑制ras法尼基转移酶。这笔赠款的一个目标是 应用是开发一种实用高效的全合成方法 CP-263,114和CP-225,917将允许生产改性 这些抑制剂的版本用于评估对ras法尼基的作用 转移酶和角鲨烯合酶。

项目成果

Investigations into a biomimetic approach toward CP-225,917 and CP-263,114.

• DOI: 10.1021/jo9911286
• 发表时间: 2000-01
• 期刊: The Journal of organic chemistry
• 作者: G. Sulikowski;F. Agnelli;R. M. Corbett

Investigations into the production and interconversion of phomoidrides A-D.

• DOI: 10.1021/ol015707k
• 发表时间: 2001-04
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: P. Spencer;F. Agnelli;G. Sulikowski

Progress toward a biomimetic synthesis of phomoidride B.

phomoidride B 的仿生合成研究进展。

• DOI: 10.1021/ol025595c
• 发表时间: 2002
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Sulikowski,GaryA;Liu,Weidong;Agnelli,Fabio;Corbett,RMichael;Luo,Zhushou;Hershberger,StefanJ
• 通讯作者: Hershberger,StefanJ

Studies on the biosynthesis of phomoidride B (CP-263,114): evidence for a decarboxylative homodimerization pathway.

phomoidride B (CP-263,114) 生物合成的研究：脱羧同二聚化途径的证据。

• DOI: 10.1021/ol025594k
• 发表时间: 2002
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Sulikowski,GaryA;Agnelli,Fabio;Spencer,Paul;Koomen,JohnM;Russell,DavidH
• 通讯作者: Russell,DavidH