A novel Hepatitis B virus genotype in Indigenous Australians: impact on vaccine efficacy and clinical outcomes

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We have recently identified a novel Hepatitis B virus (HBV) genotype (C4) circulating in Northern Territory (NT) Indigenous communities. Concurrently, epidemiological studies suggest that the HBV vaccine may not be working well and that there are high rates of liver cancer due to HBV in these communities. Our project will determine if HBV/C4 is linked to poor vaccine responses and accelerated liver disease, with implications for HBV vaccine strategy and clinical management of HBV/C4 infections.