Improving outcomes of severe bacterial infections in Northern Australia

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Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of sepsis and pneumonia in northern Australia.