A phase IIb randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis

这项随机对照试验旨在比较重症监护室治疗的重症脓毒症患者中，与标准间歇给药相比，通过连续输注给予β-内酰胺类抗生素是否能改善患者的结局。这种逐步研究计划的潜在意义在于，它可能导致一种简单且具有成本效益的干预措施，以改善重症感染患者的无ICU天数，临床治愈和生存率。

This randomised controlled trial aims to compare, in critically-ill patients with severe sepsis managed in the intensive care unit, whether the administration of beta-lactam antibiotics via continuous infusion improves outcomes for patients compared with standard intermittent dosing. The potential significance of this step-wise research program is that it may lead to a simple and cost-effective intervention to improve ICU-free days, clinical cure and survival for patients with severe infections.