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STUDY OF VASOOCCLUSION IN TRANSGENIC MICE

STUDY OF VASOOCCLUSION IN TRANSGENIC MICE
转基因小鼠血管闭塞的研究
批准号：
6449393
负责人：
Mary E Fabry
金额：
$17.52万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-04-01 至 2002-03-31
来源：
https://reporter.nih.gov/project-details/6449393
关键词：
antifungal agents arginine blood flow measurement blood vessel occlusion cell adhesion dietary aminoacid disease /disorder model enzyme inhibitors genetically modified animals histopathology hydroxyurea hypoxia kidney circulation kidney disorder laboratory mouse liver disorder magnetic resonance imaging microcirculation nitric oxide synthase noninvasive diagnosis oxygen tension pathologic process sickle cell anemia vascular endothelium

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中文摘要
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英文摘要
(Adapted from Applicant's Abstract): PI M. Fabry will use blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) and other non- invasive techniques to study the impact of factors modulating vaso- occlusion on the intact animals with particular emphasis on the liver and kidneys. The investigators will examine the effect of the modulating factors nitric oxide synthase, drugs proposed for treatment of SCD (hydroxyurea, clotrimazole, and its major metabolite) and adhesion The investigators speculate that adhesion may play a major role in the liver lesions characteristic of transgenic mice.
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会议论文
Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
MRI and NIRS in SS Patients and Mice
Core--Transgenic Mice
国内基金
海外基金
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号：
    81973577
  • 项目类别：
    面上项目
  • 资助金额：
    55.0万元
  • 批准年份：
    2019
  • 负责人：
    辛贵忠
  • 依托单位：
    中国药科大学