CORE--TRANSGENIC MICE

（摘自申请人摘要）：该核心将具有三个功能： 1)将该计划与成熟且非常成功的， 转基因和基因靶向设施可在阿尔伯特爱因斯坦 医学院。在这个设施中，将产生转基因小鼠， 用Core B提供的DNA构建体。这一职能将主要 在标签、标识和 记录创始人及其后代。2)识别 表达所需血红蛋白或红细胞转运蛋白的创始人， 描述它们的特征，并为它们的育种策略提供帮助。 创始人这些措施包括，将它们培育成表达 α H β S、α敲除、β敲除，或其他 转基因和基因敲除株系。3)培育转基因小鼠， 将被识别和表征用于项目1（两只动物 镰状细胞病器官损伤模型）;项目2（转基因 同时表达HbC和HbS和HbC;项目6（转基因小鼠 表达人K：C1共转运）。

(Adapted from Applicant's Abstract): This core will have three functions: 1) Interface the Program with the well established and highly successful, Transgenic and Gene Targeting Facility available at the Albert Einstein College of Medicine. In this facility transgenic mice will be generated with DNA constructs supplied by Core B. This function will be mainly to provide assistance to investigators in the labeling, identification and record keeping of the founders and their future generations. 2) Identify founders expressing the desired hemoglobins or red cell transporters, characterize them and provide assistance with breeding strategies of the founders. These include, breeding them to the transgenic mice expressing alphaH BetaS, the alpha-knockout, the Beta-knockouts, or to other transgenic and knockout lines available. 3) Breed transgenic mice which will be identified and characterized for use in Project 1 (Two animal models of organ damage in sickle cell disease); Project 2 (Transgenic expressing HbC and HbS and HbC simultaneously; Project 6 (Transgenic mice expression human K:C1 co-transport).