Bronx Comprehensive Sickle Cell Center

布朗克斯综合镰状细胞中心

基本信息

  • 批准号:
    7211451
  • 负责人:
  • 金额:
    $ 167.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-07-01 至 2009-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal includes: one clinical Project (Project 2: PI: Dr. Fabry) that builds on the pioneering work of the PI in the last cycle on the development of BOLD-MRI and now near infrared spectroscopy (NIRS) to measure oxygenation perfusion and blood volume in sickle cell patients and novel sickle transgenic mice. The objective is to determine if these state-of-the-art technologies can help in the evaluation of sickle damage to brain, kidney and muscle. In addition, there are three Translational Research projects that aim at finding potentially helpful therapeutic interventions in SCD by the pre-clinical development of several basic research strategies. They are: Project 1 (PI: Dr. Acharya) who is interested in generating a globin chain that has more polymerization inhibitory potential than the paradigmatic HbF, based on the pioneering finding, in the previous cycle, that pig-alpha-chain completely neutralizes human beta5-polymerization. The follow-up is to define the minimum number of pig-alpha-chain sequences that are sufficient to confer the desired properties on the human alpha-globin chain. In the process, we will learn about the quinary structure of sickle polymer as well as the refinement of semisynthesis. Project 3 (PI: Dr. Kaul). also builds on work done in the previous cycle, but the present proposal aims at a quantum leap of knowledge as it pertains to: testing the hypotheses that a heterogenous array of red cell integrins and vWF, P-selectin, laminin, and NO are involved in sickle adhesion, and testing the hypothesis that alphaVBeta3 anionic polysaccharides, and hydroxyurea, can be useful in blocking sickle cell adhesion. Project 4 (PI; Dr. Nagel), builds on a long interest in the multigene involvement in the sickle phenotype. This project aims at defining, by state-of-the art microarray technology, the genes responsible for the pleiotropic effects in sickle cell anemia, as well as which of these have epistatic (modifier) capability to define severity risk and to explore potential epigenetic effects in Beta-gene cluster haplotypes linked to the sickle gene. The projects are supported by an Administrative Core, Transgenic Core (in the forefront of developing sickle animal models), by a micro-CHIP Core (supposed also by our in-house Microarray Facility), a strong Clinical and Patient Services Core, that has pioneered the Day Hospital concept into reality, with the purpose of treating sickle cell anemia patients with uncomplicated painful crises in a way that greatly improves their rate of recovery, their hospitalization rates, and that also favorably affects the in house hospitalization length of stay. This proposal is complemented by two above-the-cap Clinical Project Proposals, both based on last cycle accomplishments.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Mary E Fabry其他文献

Mary E Fabry的其他文献

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{{ truncateString('Mary E Fabry', 18)}}的其他基金

Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
镰状细胞病中一氧化氮合酶活性的调节剂
  • 批准号:
    7654865
  • 财政年份:
    2009
  • 资助金额:
    $ 167.78万
  • 项目类别:
Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
镰状细胞病中一氧化氮合酶活性的调节剂
  • 批准号:
    7918872
  • 财政年份:
    2009
  • 资助金额:
    $ 167.78万
  • 项目类别:
MRI and NIRS in SS Patients and Mice
SS 患者和小鼠的 MRI 和 NIRS
  • 批准号:
    7406849
  • 财政年份:
    2007
  • 资助金额:
    $ 167.78万
  • 项目类别:
Core--Transgenic Mice
核心--转基因小鼠
  • 批准号:
    7406852
  • 财政年份:
    2007
  • 资助金额:
    $ 167.78万
  • 项目类别:
HYPOXIA IN SCA
SCA 缺氧
  • 批准号:
    7203420
  • 财政年份:
    2004
  • 资助金额:
    $ 167.78万
  • 项目类别:
Core--Transgenic Mice
核心--转基因小鼠
  • 批准号:
    6887396
  • 财政年份:
    2004
  • 资助金额:
    $ 167.78万
  • 项目类别:
MRI and NIRS in SS Patients and Mice
SS 患者和小鼠的 MRI 和 NIRS
  • 批准号:
    6887393
  • 财政年份:
    2004
  • 资助金额:
    $ 167.78万
  • 项目类别:
Bronx Comprehensive Sickle Cell Center
布朗克斯综合镰状细胞中心
  • 批准号:
    7463050
  • 财政年份:
    2003
  • 资助金额:
    $ 167.78万
  • 项目类别:
CORE--TRANSGENIC ANIMALS
核心——转基因动物
  • 批准号:
    6657112
  • 财政年份:
    2002
  • 资助金额:
    $ 167.78万
  • 项目类别:
DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY BOLD MRI
通过大胆 MRI 检测镰状细胞性贫血中的缺氧
  • 批准号:
    6593862
  • 财政年份:
    2002
  • 资助金额:
    $ 167.78万
  • 项目类别:

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SCTaware:一项综合计划,旨在提高新生儿筛查发现的婴儿父母对镰状细胞性状的了解和认识
  • 批准号:
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  • 财政年份:
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  • 批准号:
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  • 批准号:
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  • 财政年份:
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The Delaware Comprehensive Sickle Cell Research Center
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  • 批准号:
    8898133
  • 财政年份:
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  • 项目类别:
The Delaware Comprehensive Sickle Cell Research Center
特拉华州综合镰状细胞研究中心
  • 批准号:
    10463769
  • 财政年份:
    2014
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  • 批准号:
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  • 财政年份:
    2014
  • 资助金额:
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特拉华州综合镰状细胞研究中心
  • 批准号:
    9274317
  • 财政年份:
    2014
  • 资助金额:
    $ 167.78万
  • 项目类别:
The Delaware Comprehensive Sickle Cell Research Center
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Washington Area Comprehensive Sickle Cell Center
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    8135101
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Chicago Comprehensive Sickle Cell Center: Basic & Translational Research Program
芝加哥综合镰状细胞中心:基础
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  • 财政年份:
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  • 资助金额:
    $ 167.78万
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