A novel lipid sensitive kinase and its role in obesity-induced inflammation and insulin resistance.

一种新型脂质敏感性激酶及其在肥胖引起的炎症和胰岛素抵抗中的作用。

• 批准号: nhmrc : 586636
• 负责人: Dr Anthony Sadler
• 金额: $ 37.34万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-lipid-sensitive-insulin-resistance/101275
• 关键词: novel; lipid; sensitive; kinase; its

It is now apparent that obesity leads to chronic low grade inflammation which results in insulin resistance or pre-diabetes. The mechanisms that link obesity-induced inflammation to insulin resistance are not well understood, but involve lipid oversupply. We have preliminary data identifying that a protein, not known to previously play a role in metabolic diseases, is a critical mediator of lipid-induced inflammation. We will investigate the clinical potential of blocking this protein.

现在很明显，肥胖导致慢性低度炎症，导致胰岛素抵抗或糖尿病前期。肥胖引起的炎症与胰岛素抵抗之间的联系机制还不清楚，但涉及脂质供应过剩。我们有初步数据确定，一种以前未知在代谢疾病中发挥作用的蛋白质是脂质诱导炎症的关键介导剂。我们将研究阻断这种蛋白质的临床潜力。