Targeting cytokine signalling in systemic lupus erythematosus

系统性红斑狼疮中的靶向细胞因子信号传导

• 批准号: nhmrc : GNT1143839
• 负责人: Dr Anthony Sadler
• 金额: $ 91.76万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-cytokine-signalling-lupus-erythematosus/1348556
• 关键词: Targeting; cytokine; signalling; systemic; lupus

Systemic lupus erythematosus is a disease where the immune system attacks normally healthy tissues. The spontaneous overproduction of signalling molecules called interferons in lupus plays an important role in the severity of the disease. We have found that two proteins, named Bcl6 and PLZF, are important in controlling the interferon response in lupus patients. We propose that identifying how these proteins act to control interferon will aid in developing new treatments for lupus.

系统性红斑狼疮是一种免疫系统攻击正常健康组织的疾病。狼疮中称为干扰素的信号分子自发过度产生，对疾病的严重程度起着重要作用。我们发现，Bcl6和PLZF两种蛋白质在控制狼疮患者的干扰素反应方面起着重要作用。我们认为，确定这些蛋白质如何作用于控制干扰素将有助于开发狼疮的新治疗方法。