MYOCARDIAL VIABILITY AND PERFUSION RESERVE IMAGING

心肌活力和灌注储备成像

• 批准号: 6302129
• 负责人: THOMAS F. BUDINGER
• 金额: $ 20.06万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-07 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302129
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cardiography; clinical research; coronary bypass; coronary disorder; diagnosis design /evaluation; dogs; heart circulation; heart dimension /size; heart disorder diagnosis; heart metabolism; human subject; magnetic resonance imaging; myocardial ischemia /hypoxia; noninvasive diagnosis; perfusion; positron emission tomography; radiotracer

The purpose of this project is to develop and apply improved methods of myocardial perfusion quantitation, myocardial flow reserve and wall dynamics for the evaluation of the effects of coronary artery disease. The protocols emphasize flow quantitation using PET with applications to detection of dysfunctional reversibility and to quantitation of coronary perfusion reserve. A major hypothesis is that quantitative PET perfusion is able to show the likelihood that dysfunctional myocardial segments will recover following revascularization procedures and that perfusion quantitation is superior to fluorodeoxyglucose accumulation patterns or other contemporary non-invasive approached being used to assess viability. Forty patients who are to receive by-pass surgery will be studied. A new perfusion tracer using the 122Xe/122I generator could replace the need for an on site cyclotron and make Pet perfusion studies markedly more economical and practical in view of the new sources for 122Xe. The technological improvements in MRI could challenge PET methods for evaluation of ischemic heart disease and perfusion reserve thus these MRI methods will be compared to the best of the PET methods in years 4 and 5. Four cardiologists (three with the nuclear medicine specialty) and a cardiac radiologist have been included in addition to the medical scientist developing needed technology.

该项目的目的是开发和应用改进的 心肌灌注定量方法、心肌流量 用于评估效果的储备和壁动力学 冠状动脉疾病。 该协议强调流量定量 使用 PET 检测功能失调的应用 可逆性和冠状动脉灌注储备的定量。 一个 主要假设是定量 PET 灌注能够显示 功能失调的心肌节段恢复的可能性 血运重建手术和灌注后 定量优于氟脱氧葡萄糖积累模式 或其他当代非侵入性方法用于评估 生存能力。 四十名即将接受搭桥手术的患者将 研究过。 使用 122Xe/122I 发生器的新型灌注示踪剂 可以取代现场回旋加速器的需要并使 Pet 考虑到灌注研究明显更加经济实用 122Xe 的新来源。 技术改进在 MRI 可能会挑战 PET 评估缺血性心脏的方法 疾病和灌注储备，因此这些 MRI 方法将 与第 4 年和第 5 年最好的 PET 方法相比。四 心脏病专家（三名具有核医学专业）和一名 除了医疗人员之外，还包括心脏放射科医生 科学家开发所需的技术。