MYOCARDIAL VIABILITY AND PERFUSION RESERVE IMAGING

心肌活力和灌注储备成像

• 批准号: 6272617
• 负责人: THOMAS F. BUDINGER
• 金额: $ 20.07万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272617
• 关键词: biomedical equipment development; cardiography; clinical research; coronary bypass; coronary disorder; diagnosis design /evaluation; dogs; heart circulation; heart dimension /size; heart disorder diagnosis; heart metabolism; human subject; magnetic resonance imaging; myocardial ischemia /hypoxia; noninvasive diagnosis; perfusion; positron emission tomography; radiotracer

The purpose of this project is to develop and apply improved methods of myocardial perfusion quantitation, myocardial flow reserve and wall dynamics for the evaluation of the effects of coronary artery disease. The protocols emphasize flow quantitation using PET with applications to detection of dysfunctional reversibility and to quantitation of coronary perfusion reserve. A major hypothesis is that quantitative PET perfusion is able to show the likelihood that dysfunctional myocardial segments will recover following revascularization procedures and that perfusion quantitation is superior to fluorodeoxyglucose accumulation patterns or other contemporary non-invasive approached being used to assess viability. Forty patients who are to receive by-pass surgery will be studied. A new perfusion tracer using the 122Xe/122I generator could replace the need for an on site cyclotron and make Pet perfusion studies markedly more economical and practical in view of the new sources for 122Xe. The technological improvements in MRI could challenge PET methods for evaluation of ischemic heart disease and perfusion reserve thus these MRI methods will be compared to the best of the PET methods in years 4 and 5. Four cardiologists (three with the nuclear medicine specialty) and a cardiac radiologist have been included in addition to the medical scientist developing needed technology.

本项目的目的是开发和应用改进的 心肌灌注定量方法、心肌流量 预留物和墙体动力学用于评价的效果 冠状动脉疾病。协议强调流量量化 正电子发射计算机断层扫描在功能障碍检测中的应用 可逆性和冠脉灌注储备的定量。一个 主要的假设是定量的PET灌注能够显示 功能障碍的心肌节段恢复的可能性 在血管重建术和灌流术之后 定量测定优于氟代脱氧葡萄糖蓄积模式 或其他当代非侵入性方法被用来评估 生存能力。40名将接受旁路手术的患者将 学习。一种使用122Xe/122I发生器的新型血流示踪器 可以取代对现场回旋加速器的需求，并制作宠物 考虑到灌注研究明显更经济和实用 122Xe的新来源。在技术方面的改进 MRI可以挑战PET方法对缺血性心脏的评估 疾病和灌注储备因此这些MRI方法将是 与第四年和第四年最好的PET方法相比。 心脏病专家(三名核医学专业的)和一名 心脏放射科医生已经包括在内，除了医疗 开发所需技术的科学家。