122I GENERATOR AND RADIOTRACERS FOR PERFUSION STUDIES

描述（改编自申请人的摘要）：心脏和脑灌注 在刺激之前和之后成像（例如，双嘧达莫和乙酰唑胺， 是一个临床上重要的程序，有效地照顾 血管疾病患者。 许多不同的成像方法 已经采用了灌注，从X射线计算机断层扫描， 吸入稳定氙经颅多普勒超声，但没有一个有 分辨率、定量、器官覆盖体积和 广泛的实用性。 这个新项目是为了开发 碘-122（3.6分钟）正电子发射断层扫描（PET）示踪剂， 通过完善快速碘化化学， 122氚/122碘放射性同位素发生器的技术改进， 122 I化合物可以可靠地自动输送。 122公斤（20 hr）加拿大TRIUMF的可用性和其他来源的潜在可用性 加速器推动了这个研究项目。 脑灌注研究 用~（122）I-HIPDM对16例正常人、5例Alzheimer病患者进行了研究 患者和一名中风患者。 将选择心脏灌注剂 从最好的122 I标记的安非他明，哌嗪和丙咪嗪 季胺和鱼藤酮类化合物的研究后，在红色 细胞灌注的兔心脏制备物和狗PET研究。 比较 所选化合物将通过动态PET与13 NH和62 Cu-PTSM进行对比 在人身上。

DESCRIPTION (Adapted from Applicant's Abstract): Heart and brain perfusion imaging before and after stimulation (e.g., dipyridamole and acetazolamide, respectively) is a clinically important procedure for the efficient care of patients with vascular diseases. Many different methods for imaging perfusion have been employed, ranging from x-ray computed tomography with inhaled stable xenon to transcranial Doppler ultrasound, but none has the attributes of resolution, quantitation, volume of organ coverage and widespread practical availability. This new project is to develop iodine-122 (3.6 min) positron emission tomography (PET) tracers particularly for heart perfusion by perfecting the rapid iodination chemistry and by technological improvements of the 122Xe/122I radioisotope generator, such that 122I-compounds can be reliably and automatically delivered. 122Xe (20 hr) availability from TRIUMF, Canada and potential availability from other accelerators has motivated this research project. Brain perfusion studies with 122I-HIPDM have been completed in 16 normal subjects, 5 Alzheimer s patients and one stroke patient. Cardiac perfusion agents will be selected from the best of 122I-labeled amphetaminium, piperazinium and imipraminium quaternary amines and rotenone classes of compounds after studies in red cell perfused rabbit heart preparations and dog PET studies. Comparisons of the selected compound will be made against 13NH and 62Cu-PTSM by dynamic PET in man.