122I GENERATOR AND RADIOTRACERS FOR PERFUSION STUDIES

描述(改编自申请者摘要)：心脏和脑血流灌注 刺激前后的成像(例如，双嘧达莫和乙酰唑胺， 分别)是一种临床上重要的有效护理程序 患有血管疾病的患者。许多不同的成像方法 已经使用了灌注，范围从x射线计算机体层摄影术到 吸入稳定的氙气到经颅多普勒超声，但没有人有 分辨率、数量、器官覆盖率和 广泛的实用可用性。这个新项目是为了开发 碘-122(3.6分钟)正电子发射断层扫描(PET)示踪剂 通过完善快速碘化化学和通过 122Xe/122I放射性同位素发生器的技术改进 122I-化合物可以可靠和自动地输送。122Xe(20 HR)来自加拿大TRIUMF的可用性以及来自其他地区的潜在可用性 加速器推动了这一研究项目。脑血流灌注研究 已完成122I-HIPDM的正常人16例，阿尔茨海默病患者5例，S 患者和一名中风患者。将选择心脏灌注剂 从122I标记的苯丙胺、哌嗪和丙咪嗪中脱颖而出 红色研究后的季胺和鱼藤酮类化合物 细胞灌流的兔心制剂和狗的PET研究。比较 所选化合物将通过动态PET与13NH和62Cu-PTSM进行对比 在人类身上。

DESCRIPTION (Adapted from Applicant's Abstract): Heart and brain perfusion imaging before and after stimulation (e.g., dipyridamole and acetazolamide, respectively) is a clinically important procedure for the efficient care of patients with vascular diseases. Many different methods for imaging perfusion have been employed, ranging from x-ray computed tomography with inhaled stable xenon to transcranial Doppler ultrasound, but none has the attributes of resolution, quantitation, volume of organ coverage and widespread practical availability. This new project is to develop iodine-122 (3.6 min) positron emission tomography (PET) tracers particularly for heart perfusion by perfecting the rapid iodination chemistry and by technological improvements of the 122Xe/122I radioisotope generator, such that 122I-compounds can be reliably and automatically delivered. 122Xe (20 hr) availability from TRIUMF, Canada and potential availability from other accelerators has motivated this research project. Brain perfusion studies with 122I-HIPDM have been completed in 16 normal subjects, 5 Alzheimer s patients and one stroke patient. Cardiac perfusion agents will be selected from the best of 122I-labeled amphetaminium, piperazinium and imipraminium quaternary amines and rotenone classes of compounds after studies in red cell perfused rabbit heart preparations and dog PET studies. Comparisons of the selected compound will be made against 13NH and 62Cu-PTSM by dynamic PET in man.