CORE--METABOLIC FUNCTION AND BODY COMPOSITION

核心--代谢功能和身体成分

• 批准号: 6336223
• 负责人: KEVIN E YARASHESKI
• 金额: $ 13.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6336223
• 关键词: aging; biomedical facility; blood chemistry; blood lipid; body composition; bone density; calorimetry; computed axial tomography; frail elderly; gas chromatography mass spectrometry; geriatrics; glucose tolerance; glucose tolerance test; human subject; mass spectrometry; muscle proteins; photon absorptiometry; training

DESCRIPTION: (Adapted from applicant's abstract). The major function of this Core (RRC-D) is to support the research of the two intervention studies in this OAIC, as well as that of pilot studies supported by the OAIC. A second important function of RRC-D is to train young investigators in geriatrics and gerontology who are interested in research relevant to maintenance of functional independence of the elderly, in the performance of the procedures available within the RRC-D and in the use of stable isotope tracers in substrate turnover studies. To the extent that the investigators' time and the resources of the RRC- D permit, the RRC-D will also support other pilot and preliminary studies as well as funded studies in geriatrics and gerontology. In addition, the plan is to make the facilities and equipment of RRC-D available to young investigators in geriatrics and gerontology doing research relevant to maintenance of functional independence of the elderly. Use of the Core will be prioritized on the basis of the relevance of the research to the goal of this OAIC, which is to find effective means of preventing and reversing physical frailty and maintaining functional independence of the elderly. The specific functions of RRC-D are: a) to perform the body composition and bone quantity and quality determinations; b) to perform oral glucose tolerance tests with measurement of plasma insulin response, and obtaining blood samples for plasma lipid and lipoprotein assays; c) to perform whole body and muscle protein kinetics studies; d) to train young investigators in geriatrics and gerontology who are interested in research relevant to maintenance of functional independence of the elderly, in the performance of the above procedures and in the use of stable isotope tracers in the performance of substrate turnover studies. Performing these procedures in this Core instead of in each of the intervention studies is intended to increase efficiency by eliminating the need to have personnel trained in the performance of the procedures in these studies, and by eliminating the need to duplicate equipment. Furthermore, having all the assays performed by the same team is to enhance data quality by decreasing data variability.

描述：（改编自申请人摘要）。主要功能 本核心（RRC-D）的目的是支持两种干预措施的研究， 在这个OAIC的研究，以及由 OAIC. RRC-D的第二个重要功能是培训年轻人， 老年医学和老年学的研究人员， 与维持联合国职能独立性有关的研究 老年人，在RRC-D内可用程序的性能 以及在底物周转研究中使用稳定同位素示踪剂。 在调查员的时间和RRC的资源范围内- D许可证，RRC-D还将支持其他试点和初步 老年医学和老年学的研究以及资助的研究。在 此外，计划使RRC-D的设施和设备 提供给老年医学和老年学的年轻研究人员， 与维持联合国职能独立性有关的研究 老人核心资源的使用将根据 研究与本OAIC目标的相关性，即发现 预防和扭转身体虚弱的有效手段， 保持老年人的功能独立。具体 RRC-D的功能是：a）执行身体组成和骨骼 数量和质量测定; B）进行口服葡萄糖 通过测量血浆胰岛素反应进行耐受性试验，以及 获得用于血浆脂质和脂蛋白测定的血液样品; c） 进行全身和肌肉蛋白质动力学研究; d）训练 年轻的老年医学和老年学研究者， 与维持组织功能独立性相关的研究 老年人，在执行上述程序和使用 稳定同位素示踪剂在底物周转研究中的应用。 在此核心中执行这些程序，而不是在 干预研究旨在通过消除 需要对人员进行程序操作培训 在这些研究中，并消除了重复设备的需要。 此外，由同一个团队进行所有分析， 通过降低数据可变性来提高数据质量。