CAN EXERCISE TRAINING REVERSE PHYSICAL FRAILTY?

运动训练可以逆转身体虚弱吗？

• 批准号: 6336218
• 负责人: JOHN O. HOLLOSZY
• 金额: $ 13.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6336218
• 关键词: aerobic exercise; balance; behavioral /social science research tag; blood pressure; body composition; body physical activity; bone density; cardiac output; cognition; exercise; frail elderly; functional ability; gait; geriatrics; health care cost /financing; human old age (65+); human subject; human therapy evaluation; medical rehabilitation related tag; muscle proteins; muscle strength; oxygen consumption; physical fitness; physical therapy; protein metabolism; quality of life

DESCRIPTION: (Adapted from applicant's abstract). The major research focus of this OAIC is on the reduction of physical frailty resulting in a decrease in the risk of loss of independence and nursing home admission. The goals of this intervention study, IS-1, are: a) to determine the extent to which frail women and men over the age of 78 years can respond to exercise training with the cardiovascular, skeletal muscle, and central nervous system adaptations that have been shown to occur in younger individuals; and b) if significant adaptations do occur, to assess whether or not the magnitudes of these adaptations are sufficiently large and functionally important to result in improvements in performance of activities of daily living (ADL), instrumental ADL (IADL), advanced ADL (AADL) and in objective physical performance tests that correlate with the ability to perform IADL and AADL and are predictors of loss of independence, nursing home admission, and short- term mortality. The long-term goal is to obtain information that can be used to design practical, individualized programs of exercise that can be utilized in community settings to prevent or reverse physical frailty and maintain functional independence. The exercise training will have three phases consisting of 3 months of physical therapy exercises, 3 months of weight lifting superimposed on physical therapy exercises, and 3 months of aerobic exercise superimposed on physical therapy and weight lifting exercise. The aims of this research are to determine: a) the effectiveness of physical therapy exercises in improving flexibility, gait, balance, coordination, and strength and in reversing frailty; b) whether frail old people can adapt to weight lifting with significant increases in strength of all major muscle groups, whole body and skeletal muscle protein anabolism, and muscle mass, and a further reduction in frailty; c) whether frail old people can adapt to aerobic exercise training with increases in oxygen uptake capacity with a further decrease in frailty, and to evaluate the mechanisms involved in any increase in oxygen uptake capacity by determining maximal cardiac output, left ventricular stroke volume, and peripheral oxygen extraction; d) whether the exercise training decreases arterial stiffness; e) whether exercise training lowers blood pressure in subjects with mild hypertension; f) whether the exercise increases bone mineral density in the proximal femur, spine, and other regions of the skeleton; g) whether the exercise improves cognitive function and central processing speed; and h) whether the exercise improves quality of life. An important component of this research is to determine the extent to which the graduates from the program maintain improvements in functional capacity. Before discharge from the study, participants will be given individualized exercise prescriptions to follow at home and will be helped to put together home gyms or referred to a convenient exercise facility. Contact with the graduates will maintained by means of monthly phone calls and they will be brought back to the exercise facility once per month for a training session and periodic evaluations of functional capacity, using simple measures such as the standardized Physical Performance Test. Cost-effectiveness and cost-utility analysis will be used to evaluate the relative costs and benefits of the exercise.

描述：（改编自申请人摘要）。的主要研究 OAIC的重点是减少身体虚弱， 减少失去独立性和疗养院的风险 入院本干预研究IS-1的目标是：a） 确定78岁以上的体弱妇女和男子 年可以响应运动训练与心血管，骨骼 肌肉和中枢神经系统的适应性， 发生在较年轻的个体中;和B）如果显著的适应发生在较年轻的个体中， 发生，以评估这些适应的程度是否 足够大和功能重要，以改善 在日常生活活动（ADL）、工具性ADL （IADL），高级ADL（AADL）和客观物理性能测试 与执行IADL和AADL的能力相关， 丧失独立性、入住疗养院和短期 长期死亡率。长期目标是获取信息， 用于设计实用的、个性化的锻炼计划， 可以在社区环境中使用，以防止或扭转身体 保持功能独立性。演习训练将 有三个阶段，包括3个月的物理治疗练习， 3个月的举重加上物理治疗练习， 3个月的有氧运动加上物理治疗， 举重练习本研究的目的是确定： （a）物理治疗练习在改善 灵活性，步态，平衡，协调和力量，并在扭转 体弱; B）体弱老人能否适应举重， 所有主要肌肉群的力量显着增加，全身 和骨骼肌蛋白质，和肌肉质量，以及进一步的 c）体弱长者能否适应有氧运动 运动训练增加摄氧能力， 进一步减少虚弱，并评估参与的机制， 通过测定最大心脏负荷， 输出量、左心室每搏输出量和外周氧 提取; d）运动训练是否会减少动脉 e）运动训练是否降低受试者的血压 轻度高血压; f）运动是否增加骨矿物质 股骨近端、脊柱和骨骼其他区域的密度; g）运动是否改善认知功能和中枢神经系统 处理速度;以及h）锻炼是否改善生活质量。 这项研究的一个重要组成部分是确定 从该计划的毕业生保持功能的改善， 容量在退出研究之前，将向受试者提供 个性化的运动处方，在家里遵循，并将 帮助建立家庭健身房，或介绍一种方便的锻炼方式， 设施。与毕业生的联系将通过以下方式保持 每月电话，他们将被带回演习 每月一次的培训课程和定期评估 功能能力，使用简单的措施，如标准化 物理性能测试。成本效益和成本效用分析 将被用来评估的相对成本和效益， 锻炼的