Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

项目摘要/摘要 医疗保健系统研究网络(HCSRN)-美国老年人独立中心(OAIC) 老龄化(推进老年基础设施和网络增长)倡议，由R24赠款资助 该机制(R24 AG045050)于2014年启动，旨在促进HCSRN和OAIC(又名 胡椒中心)调查人员，以推进专注于推进 研究老年人多种慢性病(MCC)的科学。老龄化倡议是一个富有成效的、 来自18个HCSRN研究中心的科学家参与的协作、跨学科的努力，嵌入 在为近200万65岁及以上老年人提供保健服务的系统内，与 来自国家老龄研究所(The National Institute On Aging)建立的15个以大学为基础的顶级中心的调查人员 OAICs)。根据R24，与推进MCC科学有关的努力集中在：(1)表征 和共享独特的数据资源；(2)支持创新、协作的试点项目；(3)指导新的 和早期调查人员；(4)传播研究方法和成果。此次协作具有 确定了几个研究不足、高度优先的研究领域，以及对正式职业的迫切需要 为致力于老龄化病因、预防和研究的新科学家和早期科学家提供开发支持 和治疗，与照顾患有MCC的老年人有关。我们扩展的R33的首要目标是 计划，由R24 HCSRN-OAICs老龄化倡议指导委员会构思和开发，其 工作组和外部咨询委员会，将详细阐述成功的方案和基础设施 R24，同时将我们的老龄化倡议带向新的、更雄心勃勃的方向。我们将创建新的核心 资源、职业发展机会和资金机会，使患者的利益与这些 科学家的身份。我们的具体目标是：(1)拓展和进一步发展与以下相关的创新方法 测量和分析、观察性研究以及实用的临床试验设计和实施，以 告知制定和测试新的干预措施，以改善老年人的护理和结果 (2)促进新的和早期调查人员的职业发展和成功，包括 代表不足的少数群体，并在全国范围内建立一批MCC学者，他们准备建立 在职业生涯早期进行富有成效的合作，以促进与以下领域相关的跨学科研究的扩展 MCC的科学；(3)创建一个新的核心功能，作为促进 以患者为中心的研究，让患者和护理伙伴参与研究过程的所有阶段；以及 (4)资助一系列“P-2-R”(“飞行员对R奖励”)拨款，以推进相关的R33研究优先事项 为MCC科学干杯。“P-2-R”赠款将用于促进发展和执行 更大规模、多学科、多地点的研究为继续老龄化奠定了基础 主动权。

PROJECT SUMMARY / ABSTRACT The Health Care Systems Research Network (HCSRN)-Older Americans Independence Centers (OAICs) AGING (Advancing Geriatrics Infrastructure and Network Growth) Initiative, funded under an R24 grant mechanism (R24 AG045050), was initiated in 2014 to foster collaborations between HCSRN and OAIC (aka Pepper Centers) investigators in order to advance an interdisciplinary research agenda focused on advancing the science of multiple chronic conditions (MCCs) in older adults. The AGING Initiative is a highly productive, collaborative, transdisciplinary endeavor involving scientists from 18 HCSRN research centers, embedded within healthcare delivery systems caring for nearly 2 million persons aged 65 and older, in partnership with investigators from 15 premier, university-based centers established by the National Institute on Aging (the OAICs). Under the R24, efforts relevant to advancing MCCs science have centered around: (1) characterizing and sharing unique data resources; (2) supporting innovative, collaborative pilot projects; (3) mentoring new and early-stage investigators; and (4) disseminating research methods and findings. This collaboration has identified several understudied, high priority research domains, as well as an urgent need for formal career development support for new and early-stage scientists committed to aging research on etiology, prevention, and treatment, relevant to the care of older persons with MCCs. The overarching aim of our expanded R33 program, conceived and developed by the R24 HCSRN-OAICs AGING Initiative Steering Committee, and its Workgroups and External Advisory Committee, is to elaborate on the successful programs and infrastructure of the R24, while taking our AGING Initiative in new, more ambitious directions. We will create new core resources, career development opportunities, and funding opportunities, aligning patients' interests with those of scientists. Our specific aims are: (1) to expand on and further develop innovative methods related to measurement and analytics, observational research, and pragmatic clinical trial design and implementation, to inform the development and testing of novel interventions that improve the care and outcomes of older persons with MCCs; (2) to foster the career development and success of new and early-stage investigators, including underrepresented minorities, and create a nation-wide cohort of MCCs scholars, who are prepared to establish productive collaborations early in their careers to catalyze an expansion of interdisciplinary research relevant to the science of MCCs; (3) to create a new core function as part of an elaborated infrastructure that promotes patient-centered research by engaging patients and care partners in all stages of the research process; and (4) to fund a series of “P-2-R” (“Pilot-to-R award”) grants that will advance the R33 research priorities relevant to the science of MCCs. The “P-2-R” grants will serve to promote the development and implementation of larger, multi-disciplinary, multi-site studies laying a foundation upon which to continue to grow the AGING Initiative.