Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

推进老年病学基础设施

• 批准号: 9752439
• 负责人: JERRY H GURWITZ
• 金额: $ 73.43万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752439
• 关键词: Address; Advisory Committees; Aging; American; Award; Capsicum; Caring; Chronic; Clinical Research; Clinical Trials Design; Collaborations; Data; Development; Disease; Elderly; Electronic Health Record; Etiology; Exploratory/Developmental Grants Phase II; Fostering; Foundations; Funding; Funding Opportunities; Geriatrics; Grant; Growth; Healthcare Systems; Infrastructure; Interdisciplinary Study; Intervention; Measurement; Mentors; Methods; Minority Groups; Monoclonal Antibody R24; National Institute on Aging; Network Infrastructure; Observational Study; Older Population; Patient Care; Patients; Persons; Pilot Projects; Population; Pragmatic clinical trial; Prevention; Process; Quality of Care; Research; Research Methodology; Research Personnel; Research Priority; Research Support; Resources; Science; Scientist; Series; Site; Speed; Testing; Translating; Underrepresented Groups; Underrepresented Minority; Universities; base; care outcomes; care systems; career; career development; clinical decision-making; clinical practice; cohort; cost; data resource; health care delivery; human old age (65+); improved; innovation; interest; multidisciplinary; multiple chronic conditions; novel; patient oriented; patient population; preference; programs; success; systems research

PROJECT SUMMARY / ABSTRACT The Health Care Systems Research Network (HCSRN)-Older Americans Independence Centers (OAICs) AGING (Advancing Geriatrics Infrastructure and Network Growth) Initiative, funded under an R24 grant mechanism (R24 AG045050), was initiated in 2014 to foster collaborations between HCSRN and OAIC (aka Pepper Centers) investigators in order to advance an interdisciplinary research agenda focused on advancing the science of multiple chronic conditions (MCCs) in older adults. The AGING Initiative is a highly productive, collaborative, transdisciplinary endeavor involving scientists from 18 HCSRN research centers, embedded within healthcare delivery systems caring for nearly 2 million persons aged 65 and older, in partnership with investigators from 15 premier, university-based centers established by the National Institute on Aging (the OAICs). Under the R24, efforts relevant to advancing MCCs science have centered around: (1) characterizing and sharing unique data resources; (2) supporting innovative, collaborative pilot projects; (3) mentoring new and early-stage investigators; and (4) disseminating research methods and findings. This collaboration has identified several understudied, high priority research domains, as well as an urgent need for formal career development support for new and early-stage scientists committed to aging research on etiology, prevention, and treatment, relevant to the care of older persons with MCCs. The overarching aim of our expanded R33 program, conceived and developed by the R24 HCSRN-OAICs AGING Initiative Steering Committee, and its Workgroups and External Advisory Committee, is to elaborate on the successful programs and infrastructure of the R24, while taking our AGING Initiative in new, more ambitious directions. We will create new core resources, career development opportunities, and funding opportunities, aligning patients' interests with those of scientists. Our specific aims are: (1) to expand on and further develop innovative methods related to measurement and analytics, observational research, and pragmatic clinical trial design and implementation, to inform the development and testing of novel interventions that improve the care and outcomes of older persons with MCCs; (2) to foster the career development and success of new and early-stage investigators, including underrepresented minorities, and create a nation-wide cohort of MCCs scholars, who are prepared to establish productive collaborations early in their careers to catalyze an expansion of interdisciplinary research relevant to the science of MCCs; (3) to create a new core function as part of an elaborated infrastructure that promotes patient-centered research by engaging patients and care partners in all stages of the research process; and (4) to fund a series of “P-2-R” (“Pilot-to-R award”) grants that will advance the R33 research priorities relevant to the science of MCCs. The “P-2-R” grants will serve to promote the development and implementation of larger, multi-disciplinary, multi-site studies laying a foundation upon which to continue to grow the AGING Initiative.

项目摘要/摘要 医疗保健系统研究网络（HCSRN）-美国老年人独立中心（OAIC） AGING（推进老年医学基础设施和网络增长）倡议，由R24赠款资助 机制（R24 AG045050）于2014年启动，旨在促进HCSRN和OAIC（又名 胡椒中心）的调查人员，以推进跨学科的研究议程，重点是推进 老年人多种慢性病（MCC）的科学。老龄化倡议是一个高生产力， 来自18个HCSRN研究中心的科学家参与了跨学科的合作， 在医疗保健提供系统中，与以下机构合作，为近200万65岁及以上的人提供护理： 调查人员来自15个主要的大学中心，由国家老龄问题研究所（The OAIC）。在R24下，与推进MCC科学相关的努力集中在：（1）表征 （2）支持创新的、合作的试点项目;（3）指导新的 （4）传播研究方法和研究成果。这种合作 确定了几个研究不足，高优先级的研究领域，以及对正式职业的迫切需要 为致力于衰老病因学，预防， 和治疗，与照顾患有MCC的老年人有关。我们扩展的R33的首要目标是 该计划由R24 HCSRN-OAIC老龄化倡议指导委员会构思和开发， 工作组和外部咨询委员会，是阐述成功的方案和基础设施， R24，同时将我们的老龄化倡议推向新的，更雄心勃勃的方向。我们将创造新的核心 资源，职业发展机会和资金机会，使患者的利益与这些利益保持一致 科学家们。我们的具体目标是：（1）扩大和进一步发展与以下方面有关的创新方法： 测量和分析，观察性研究，实用的临床试验设计和实施， 为制定和测试改善老年人护理和成果的新干预措施提供信息 （2）促进新的和早期阶段的调查人员的职业发展和成功，包括 代表性不足的少数民族，并创建一个全国性的MCC学者队列，他们准备建立 在他们职业生涯的早期进行富有成效的合作，以促进相关跨学科研究的扩展， MCC科学;（3）创建一个新的核心功能，作为精心设计的基础设施的一部分， 以患者为中心的研究，让患者和护理伙伴参与研究过程的各个阶段; (4)资助一系列“P-2-R”（“Pilot-to-R奖”）赠款，以推进R33研究优先事项的相关研究。 对MCC科学的贡献"P-2-R"赠款将用于促进 更大的，多学科的，多地点的研究奠定了基础，在此基础上继续增长的老龄化 倡议