MR IMAGING OF CHONDROCYTE TRANSPLANTATION

软骨细胞移植的磁共振成像

• 批准号: 6309973
• 负责人: GABRIELLE BERGMAN
• 金额: $ 1.55万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309973
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; musculoskeletal system; technology /technique

Introduction: During 1996-97 we performed a pilot study to evaluate how well MR can be used to study changes after a chondrocyte transplantation, a recently described procedure that may lead to reconstitution of articular cartilage which has been damaged by an injury or osteoarthritis. Methods/Results: We evaluated several MR sequences aimed at characterizing cartilage and underlying bone marrow signal changes, as well as contour changes of the transplant. These have included fast spin-echo, SSMT, and a spectroscopy sequence developed by Dr. Garry Gold. The first person to undergo the chondrocyte transplant procedure (Carticel; Genzyme, Inc.) at Stanford has been followed with MR exams performed every 3-4 months for a year, and a few other patients have had MR exams as well. We are planning to examine 12 patients over 2 years post-Carticel procedure, with support from Genzyme, and use other cartilage MR sequences under development as well, such as diffusion imaging, to study these patients. Conclusions: We have shown that subarticular bone marrow edema disappeared within a few months after the chondrocyte transplant, and a smooth surface was formed over the focal cartilage defect that was treated.

导言：在1996-97年期间，我们进行了一项试验性研究， 评估MR如何用于研究软骨细胞植入后的变化， 移植，最近描述的程序，可能会导致 关节软骨的重建， 损伤或骨关节炎。 方法/结果：我们评估了几种MR 旨在表征软骨和骨髓的序列 信号变化以及移植物的轮廓变化。 这些 包括快速自旋回波、SSMT和光谱序列 由加里·戈尔德博士研发 第一个接受 软骨细胞移植程序（Carticel; Genzyme，Inc.）在斯坦福大学 每3-4个月进行一次MR检查，持续一年， 还有一些病人也做了磁共振检查 我们计划 在Carticel手术后2年内检查12例患者， 由Genzyme支持，并使用其他软骨MR序列， 发展，以及，如扩散成像，研究这些 患者 结论：我们已经表明，关节下骨髓 水肿消失后，几个月内软骨细胞 移植，并在病灶软骨上形成光滑表面 已处理的缺陷。