A novel oncogenic alliance in breast cancer

乳腺癌的新型致癌联盟

• 批准号: nhmrc : 1129794
• 负责人: Dr Lisa Ooms
• 金额: $ 49.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-oncogenic-alliance-breast-cancer/948466
• 关键词: novel; oncogenic; alliance; breast; cancer

Triple negative breast cancer (TNBC) is an aggressive disease subtype that lacks targeted therapies. We have identified a protein associated with TNBC termed SgK269 that regulates the transmission of signals instructing the cell to grow and migrate. SgK269 associates with a closely-related protein termed SgK223 to form a signalling complex. The aim of this project is to characterise the role of this signalling complex in TNBC and determine whether it represents a potential therapeutic target.

三阴性乳腺癌（TNBC）是一种缺乏靶向治疗的侵袭性疾病亚型。我们已经鉴定出一种与 TNBC 相关的蛋白质，称为 SgK269，它调节指示细胞生长和迁移的信号传输。 SgK269 与一种密切相关的称为 SgK223 的蛋白质结合形成信号复合物。该项目的目的是表征该信号复合物在 TNBC 中的作用，并确定它是否代表潜在的治疗靶点。