Role of INPP4B and related proteins in human cancer.

INPP4B 和相关蛋白在人类癌症中的作用。

• 批准号: nhmrc : 1044737
• 负责人: Dr Lisa Ooms
• 金额: $ 43.39万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-inpp4b-related-human-cancer/111684
• 关键词: Role; INPP4B; related; proteins; human

Breast cancer is the most common malignancy among females, affecting 1 in 9 women. Cells normally divide only when they receive a stimulus. The PI3K pathway, which responds to these stimuli, has been implicated in cancer and when mutated induces cells to multiply uncontrollably and invade surrounding tissue. This grant aims to characterise the role of a cancer suppressing gene and a related family member play in the development of human breast cancer.

乳腺癌是女性中最常见的恶性肿瘤，每9名女性中就有1人受到影响。细胞通常只有在受到刺激时才会分裂。对这些刺激做出反应的PI3K通路与癌症有关，当突变时会诱导细胞失控繁殖并侵袭周围组织。这项拨款旨在描述一种癌症抑制基因及其相关家庭成员在人类乳腺癌发展过程中所扮演的角色。