A novel treatment for ischemic stroke: preclinical assessment in the nonhuman primate

缺血性中风的新疗法：非人灵长类动物的临床前评估

• 批准号: nhmrc : 1080197
• 负责人: A/Pr James Bourne
• 金额: $ 50.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-treatment-ischemic-nonhuman-primate/518727
• 关键词: novel; treatment; ischemic; stroke; preclinical

A major source of repair inhibition after brain injury is debris from dying cells, which contains proteins that hinder repair. This project will examine the expression of these proteins in a clinically-relevant model of ischemic stroke and determine if blocking the effect of these proteins neutralises their repair-inhibiting properties. If successful, there is likelihood that this drug, and method of delivery, could be translated into the human for treatment following an ischemic stroke.

脑损伤后修复抑制的主要来源是垂死细胞的碎片，其中含有阻碍修复的蛋白质。该项目将在临床相关的缺血性中风模型中检测这些蛋白质的表达，并确定阻断这些蛋白质的作用是否会中和它们的修复抑制特性。如果成功的话，这种药物和递送方法有可能转化为人类用于缺血性中风后的治疗。