Molecular and Cellular Changes Following a Cortical Injury: What Role Do They Play in Regeneration?

皮质损伤后的分子和细胞变化：它们在再生中发挥什么作用？

• 批准号: nhmrc : 1002049
• 负责人: A/Pr James Bourne
• 金额: $ 33.32万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-cellular-changes-play-regeneration/108767
• 关键词: Molecular; Cellular; Changes; Following; Cortical

Damage to the visual areas of the brain is common after, for example stroke, neurotrauma or hypoxia. The injury often manifests in the form of a scar caused by a specific type of brain cell (astrocyte). This scar acts as a barrier to the cells which transmit information (neurones), preventing re-establishment of connectivity, thus functional recovery. We will see if we can reduce this scar and enhance re-connectivity after injury by blocking some of the molecules that brain cells express.

脑视觉区的损伤在例如中风、神经创伤或缺氧之后是常见的。损伤通常表现为由特定类型的脑细胞（星形胶质细胞）引起的疤痕形式。这种疤痕作为传递信息的细胞（神经元）的屏障，阻止连接的重建，从而阻止功能恢复。我们将看看我们是否可以通过阻断脑细胞表达的一些分子来减少这种疤痕并增强损伤后的重新连接。