MBRS PROGRAM

这项建议要求继续支持非常成功的 南科罗拉多大学MBRS项目。 的目标 这项计划的目的是增加少数民族学生的数量， 获得生物医学科学的高级学位，并加强 为南加州大学的教师和学生提供研究机会， 为少数民族社区和学生服务的机构 人口 学生的发展成为生产力，成熟， 伦理科学家是首要目标。 为了实现这些目标， 这份建议书描述了八个研究项目，涵盖以下领域： 生物学、化学、心理学和人类行为研究。 八个研究项目包括两个化学项目，两个生物项目， 生物化学和人类行为研究各一个 之一 生物学项目研究了M1金属的作用， 氨基肽酶基因在酵母细胞生理学中的作用。 第二生物学 研究子宫蛋白酶活性对胚胎的影响 置入 生物化学项目旨在表征和 确定真菌酸性磷酸酶的功能， 与哺乳动物抗酒石酸盐的 在细胞白血病中过度表达的酸性磷酸酶。 一 化学项目探索药物化合物的合成路线 通过化学反应。 第二个化学项目的目标 是通过设计选择性的， 用于色谱分离的特定材料 大药厂 其中一个心理学项目调查了 神经肽及其受体在控制 乙醇动物模型中的自愿酒精偏好 消费 第二个心理学项目考察了 盐的食欲和神经生理变化之间的关系。 人类行为研究项目考察了心理和 有助于维持体育活动的社会因素 和健康的影响。 之多样 该项目和教师的研究人员预计将吸引和 积极让学生参与富有成效的研究经验， 准备研究生生物医学课程。

This proposal requests continued support for the highly successful MBRS Program at the University of Southern Colorado (USC). The goals of this program are to increase the number of minority students attaining advanced degrees in the biomedical sciences and to enhance research opportunities for faculty and students at USC, an institution that serves a large minority community and student population. The development of students into productive, mature, and ethical scientists is a primary objective. To achieve these goals, this proposal describes eight research projects spanning the areas of biology, chemistry, psychology, and human performance studies. The eight research projects include two in chemistry, two in biology, and one each in biochemistry and human performance studies. One of the biology projects investigates the role of the M1 metallo- aminopeptidase gene in yeast cell physiology. The second biology project examines the effect of uterine proteinase activity on embryo implantation. The biochemistry project seeks to characterize and determine the function of fungal acid phosphatases that exhibit a high degree of sequence homology to the mammalian tartrate-resistant acid phosphatases that are overly expressed in cell leukemia. One chemistry project explores synthetic routes to medicinal compounds via fluorination reactions. The second chemistry project's objective is to advance biomedical research through the design of selective and specific materials for chromatographic separations of pharmaceuticals. One of the psychology projects investigates the function of neuropeptides and their receptors in the control of voluntary alcohol preferences in an animal model of ethanol consumption. The second psychology project examines the relationship between salt appetite and neural physiological changes in the rat. The human performance studies project examines the psychological and social factors that contribute to maintenance of physical activities and health in a Hispanic church-based population. The diversity of the projects and the faculty researchers is expected to attract and actively engage students in productive research experiences as preparation for graduate biomedical programs.