CRYO ELECTRON MICROSCOPY & MACROMOLECULAR IMAGING

本项目的目标是检查职能组织 指控制手和手臂运动的人类初级运动皮质。通过 我们将使用多种成像方式来确定这种关系 在初级运动皮质的激活之间。由以下指标衡量 功能磁共振成像(FMRI)与光学本征 信号(OIS)和皮层刺激所获得的运动图。 通过研究一组接受清醒开颅手术的患者，我们将 有一个独特的机会来验证非侵入性测绘技术 用直接的皮质测量。这将有助于建立 功能磁共振成像在术前标测中的作用及为研究奠定基础 在神经系统疾病中人类运动功能的恢复。 具体目标 假设1：人类初级运动皮质控制手臂和手 运动的特征是功能相关的重叠区域， 这将通过fMR.1和光学本征信号来证明。 假设2：初级运动皮质图之间的差异 通过直接皮质刺激获得的FMR1和OIS将产生 以更好地了解潜在的生理特性 这些信号最终会更好地定位大脑皮质 手术患者的功能。假设3：初级运动皮质是 在想象的动作中被激活。

The goal of this project is to examine the functional organization of human primary motor cortex controlling hand and arm movements. By using multiple imaging modalities we will determine the relationship between activations in primary Motor cortex. as measured by functional magnetic resonance imaging (fMRI) and optical intrinsic signaling (OIS), and the motor map obtained by cortical stimulation. By studying a group of patients undergoing awake craniotomy we will have a unique opportunity to validate non-invasive mapping techniques with direct cortical measurements. This will serve to establish the role of fMRI in presurgical mapping and lay the foundation for studies of recovery of human motor function in neurological disease. Specific Aims Hypothesis 1: Human primary motor cortex controlling arm and hand movement is characterized by functionally related overlapping regions, which will be demonstrable by fMR.1 and optical intrinsic signaling. Hypothesis 2: Discrepancies between the maps of primary motor cortex obtained by direct cortical stimulation, fMR1 and OIS will give rise to a better understanding of the physiologic properties underlying these signals and ultimately to better localization of cortical function in surgical patients. Hypothesis 3: Primary motor cortex is activated during imagined movements.